Publications

  1. Finding the sweet spot for chaperone activity. Radford, Sheena E. and Karamanos, Theodoros K. (2021) Nature Chemistry, 13, 397-399. doi:10.1038/s41557-021-00691-5, Early Access Date = APR 2021
  2. Brazilin removes toxic alpha-synuclein and seeding competent assemblies from parkinson brain by altering conformational equilibrium. Nahass, George R. , Sun, Yuanzi , Xu, Yong , Batchelor, Mark , Reilly, Madeleine , Benilova, Iryna , Kedia, Niraja , Spehar, Kevin , Sobott, Frank , Sessions, Richard B. , Caughey, Byron , Radford, Sheena E. , Jat, Parmjit S. , Collinge, John and Bieschke, Jan (2021) Journal of Molecular Biology, 433, . doi:10.1016/j.jmb.2021.166878
  3. De novo design of transmembrane beta barrels. Vorobieva, Anastassia A. , White, Paul , Liang, Binyong , Horne, Jim E. , Bera, Asim K. , Chow, Cameron M. , Gerben, Stacey , Marx, Sinduja , Kang, Alex , Stiving, Alyssa Q. , Harvey, Sophie R. , Marx, Dagan C. , Khan, G. Nasir , Fleming, Karen G. , Wysocki, Vicki H. , Brockwell, David J. , Tamm, Lukas K. , Radford, Sheena E. and Baker, David (2021) Science, 371, 801+. doi:10.1126/science.abc8182
  4. Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for Type II diabetes. Milardi, Danilo , Gazit, Ehud , Radford, Sheena E. , Xu, Yong , Gallardo, Rodrigo U. , Caflisch, Amedeo , Westermark, Gunilla T. , Westermark, Per , La Rosa, Carmelo and Ramamoorthy, Ayyalusamy (2021) Chemical Reviews, 121, 1845-1893. doi:10.1021/acs.chemrev.0c00981
  5. Investigation of D76N β2-microglobulin using protein footprinting and structural mass spectrometry. Cornwell, Owen , Ault, James R , Bond, Nicholas J , Radford, Sheena E and Ashcroft, Alison E (2021) Journal of the American Society for Mass Spectrometry, , . doi:
  6. Visualizing and trapping transient oligomers in amyloid assembly pathways. Cawood, Emma E. , Karamanos, Theodoros K. , Wilson, Andrew J. and Radford, Sheena E. (2021) Biophysical Chemistry, 268, . doi:10.1016/j.bpc.2020.106505
  7. Modulation of amyloidogenic protein self-assembly using tethered small molecules. Cawood, Emma E. , Guthertz, Nicolas , Ebo, Jessica S. , Karamanos, Theodoros K. , Radford, Sheena E. and Wilson, Andrew J. (2020) Journal of the American Chemical Society, 142, 20845-20854. doi:10.1021/jacs.0c10629
  8. Distortion of the bilayer and dynamics of the BAM complex in lipid nanodiscs. Iadanza, Matthew G. , Schiffrin, Bob , White, Paul , Watson, Matthew A. , Horne, Jim E. , Higgins, Anna J. , Calabrese, Antonio N. , Brockwell, David J. , Tuma, Roman , Kalli, Antreas C. , Radford, Sheena E. and Ranson, Neil A. (2020) Communications Biology, 3, . doi:10.1038/s42003-020-01419-w
  9. Looking beyond the core: the role of flanking regions in the aggregation of amyloidogenic peptides and proteins. Ulamec, Sabine M. , Brockwell, David J. and Radford, Sheena E. (2020) Frontiers in Neuroscience, 14, . doi:10.3389/fnins.2020.611285
  10. Modulation of beta-amyloid fibril formation in Alzheimer's disease by microglia and infection. Brown, Madeleine R. , Radford, Sheena E. and Hewitt, Eric W. (2020) Frontiers in Molecular Neuroscience, 13, . doi:10.3389/fnmol.2020.609073
  11. Structural insights into peptide self-assembly using photo-induced crosslinking experiments and discontinuous molecular dynamics. Bunce, Samuel J. , Wang, Yiming , Radford, Sheena E. , Wilson, Andrew J. and Hall, Carol K. (2020) Aiche Journal, , . doi:10.1002/aic.17101
  12. The uniqueness of flow in probing the aggregation behavior of clinically relevant antibodies. Willis, Leon F. , Kumar, Amit , Jain, Tushar , Caffrey, Isabelle , Xu, Yingda , Radford, Sheena E. , Kapur, Nikil , Vasquez, Maximiliano and Brockwell, David J. (2020) Engineering Reports, 27, 1094. doi:10.1002/eng2.12147
  13. Fibril structures of diabetes-related amylin variants reveal a basis for surface-templated assembly. Gallardo, Rodrigo , Iadanza, Matthew G. , Xu, Yong , Heath, George R. , Foster, Richard , Radford, Sheena E. and Ranson, Neil A. (2020) Nature Structural & Molecular Biology, 27, 1094. doi:10.1038/s41594-020-00525-x, Early Access Date = OCT 2020
  14. Potential human transmission of amyloid beta pathology: surveillance and risks. Lauwers, Elsa , Lalli, Giovanna , Br,ner, Sebastian , Collinge, John , Compernolle, Veerle , Duyckaerts, Charles , Edgren, Gustaf , Haik, Stephane , Hardy, John , Helmy, Adel , Ivinson, Adrian J. , Jaunmuktane, Zane , Jucker, Mathias , Knight, Richard , Lemmens, Robin , Lin, I-Chun , Love, Seth , Mead, Simon , Perry, V. Hugh , Pickett, James , Poppy, Guy , Radford, Sheena E. , Rousseau, Frederic , Routledge, Carol , Schiavo, Giampietro , Schymkowitz, Joost , Selkoe, Dennis J. , Smith, Colin , Thal, Dietmar R. , Theys, Tom , Tiberghien, Pierre , van den Burg, Peter , V,ekerckhove, Philippe , Walton, Clare , Zaaijer, Hans L. , Zetterberg, Henrik and De Strooper, Bart (2020) Lancet Neurology, 19, 872-878. doi:
  15. The role of the IT-state in D76N beta(2)-microglobulin amyloid assembly: a crucial intermediate or an innocuous bystander?. Smith, I, Hugh , Guthertz, Nicolas , Cawood, Emma E. , Maya-Martinez, Roberto , Breeze, Alex,er L. and Radford, Sheena E. (2020) Journal of Biological Chemistry, 295, 12474-12484. doi:10.1074/jbc.RA120.014901
  16. Spot the difference: function versus toxicity in amyloid fibrils. Ulamec, Sabine M. and Radford, Sheena E. (2020) Trends in Biochemical Sciences, 45, 635-636. doi:10.1016/j.tibs.2020.04.007
  17. Role of the lipid bilayer in outer membrane protein folding in gram-negative bacteria. Horne, Jim E. , Brockwell, David J. and Radford, Sheena E. (2020) Journal of Biological Chemistry, 295, 10340-10367. doi:10.1074/jbc.REV120.011473
  18. Macromolecular crowding enhances the detection of DNA and proteins by a solid-state nanopore. Chau, Chalmers C. , Radford, Sheena E. , Hewitt, Eric W. and Actis, Paolo (2020) Nano Letters, 20, 5553-5561. doi:10.1021/acs.nanolett.0c02246
  19. Pyxlinkviewer: a flexible tool for visualization of protein chemical crosslinking data within thepymolmolecular graphics system. Schiffrin, Bob , Radford, Sheena E. , Brockwell, David J. and Calabrese, Antonio N. (2020) Protein Science, 29, 1851-1857. doi:10.1002/pro.3902, Early Access Date = JUL 2020
  20. Structural insight into the formation of lipoprotein-beta-barrel complexes. Rodriguez-Alonso, Raquel , Letoquart, Juliette , Van Son Nguyen , Louis, Gwennaelle , Calabrese, Antonio N. , Iorga, Bogdan I. , Radford, Sheena E. , Cho, Seung-Hyun , Remaut, Han and Collet, Jean-Francois () Nature Chemical Biology, , . doi:10.1038/s41589-020-0575-0, Early Access Date = JUN 2020
  21. Inter-domain dynamics in the chaperone SurA and multi-site binding to its outer membrane protein clients. Calabrese, Antonio N. , Schiffrin, Bob , Watson, Matthew , Karamanos, Theodoros K. , Walko, Martin , Humes, Julia R. , Horne, Jim E. , White, Paul , Wilson, Andrew J. , Kalli, Antreas C. , Tuma, Roman , Ashcroft, Alison E. , Brockwell, David J. and Radford, Sheena E. (2020) Nature Communications, 11, . doi:10.1038/s41467-020-15702-1
  22. An in vivo platform to select and evolve aggregation-resistant proteins. Ebo, Jessica S. , Saunders, Janet C. , Devine, Paul W. A. , Gordon, Alice M. , Warwick, Amy S. , Schiffrin, Bob , Chin, Stacey E. , Engl,, Elizabeth , Button, James D. , Lloyd, Christopher , Bond, Nicholas J. , Ashcroft, Alison E. , Radford, Sheena E. , Lowe, David C. and Brockwell, David J. (2020) Nature Communications, 11, . doi:10.1038/s41467-020-15667-1
  23. A short motif in the N-terminal region of alpha-synuclein is critical for both aggregation and function. Doherty, Ciaran P. A. , Ulamec, Sabine M. , Maya-Martinez, Roberto , Good, Sarah C. , Makepeace, Jemma , Khan, G. Nasir , van Oosten-Hawle, Patricija , Radford, Sheena E. and Brockwell, David J. (2020) Nature Structural & Molecular Biology, 27, 249+. doi:10.1038/s41594-020-0384-x
  24. Amyloid structures: much more than just a cross-beta fold. Gallardo, Rodrigo , Ranson, Neil A. and Radford, Sheena E. (2020) Current Opinion in Structural Biology, 60, 7-16. doi:10.1016/j.sbi.2019.09.001
  25. Using protein engineering to understand and modulate aggregation. Ebo, Jessica S. , Guthertz, Nicolas , Radford, Sheena E. and Brockwell, David J. (2020) Current Opinion in Structural Biology, 60, 157-166. doi:10.1016/j.sbi.2020.01.005
  26. Collagen I weakly interacts with the beta-sheets of beta(2)-microglobulin and enhances conformational exchange to induce amyloid formation. Hoop, Cody L. , Zhu, Jie , Bhattacharya, Shibani , Tobita, Caitlyn A. , Radford, Sheena E. and Baum, Jean (2020) Journal of the American Chemical Society, 142, 1321-1331. doi:10.1021/jacs.9b10421
  27. Homage to Chris Dobson. Baum, Jean , Chiti, Fabrizio , De Simone, Alfonso , Knowles, Tuomas P. J. , Kumita, Janet R. , Radford, Sheena E. , Robinson, Carol V. , Salvatella, Xavier , Valelli, Karen , Vendruscolo, Michele , Pastore, Annalisa and Tartaglia, Gian Gaetano (2019) Frontiers in Molecular Biosciences, 6, . doi:10.3389/fmolb.2019.00137
  28. Long-range conformational changes in monoclonal antibodies revealed using FPOP-LS-MS/MS. Cornwell, Owen , Bond, Nicholas J. , Radford, Sheena E. and Ashcroft, Alison E. (2019) Analytical Chemistry, 91, 15163-15170. doi:10.1021/acs.analchem.9b03958
  29. Structural mapping of oligomeric intermediates in an amyloid assembly pathway. Karamanos, Theodoros K. , Jackson, Matthew P. , Calabrese, Antonio N. , Goodchild, Sophia C. , Cawood, Emma E. , Section, Gary S. Thompson , Kalverda, Arnout P. , Hewitt, Eric W. and Radford, Sheena E. (2019) Elife, 8, . doi:10.7554/eLife.46574
  30. Extracellular matrix components modulate different stages in (2)-microglobulin amyloid formation. Benseny-Cases, Nuria , Karamanos, Theodoros K. , Hoop, Cody L. , Baum, Jean and Radford, Sheena E. (2019) Journal of Biological Chemistry, 294, 9392-9401. doi:10.1074/jbc.RA119.008300
  31. Molecular insights into the surface-catalyzed secondary nucleation of amyloid-beta(40) (a beta(40)) by the peptide fragment a beta(16-22). Bunce, Samuel J. , Wang, Yiming , Stewart, Katie L. , Ashcroft, Alison E. , Radford, Sheena E. , Hall, Carol K. and Wilson, Andrew J. (2019) Science Advances, 5, . doi:10.1126/sciadv.aav8216
  32. Dual role of ribosome-binding domain of nac as a potent suppressor of protein aggregation and aging-related proteinopathies. Shen, Koning , Gamerdinger, Martin , Chan, Rebecca , Gense, Karina , Martin, Esther M. , Sachs, Nadine , Knight, Patrick D. , Schloemer, Renate , Calabrese, Antonio N. , Stewart, Katie L. , Leiendecker, Lukas , Baghel, Ankit , Radford, Sheena E. , Frydman, Judith and Deuerling, Elke (2019) Molecular Cell, 74, 729+. doi:10.1016/j.molcel.2019.03.012
  33. The role of SurA pplase domains in preventing aggregation of the outer-membrane proteins tOmpA and OmpT. Humes, Julia R. , Schiffrin, Bob , Calabrese, Antonio N. , Higgins, Anna J. , Westhead, David R. , Brockwell, David J. and Radford, Sheena E. (2019) Journal of Molecular Biology, 431, 1267-1283. doi:10.1016/j.jmb.2019.01.032
  34. Thermodynamic phase diagram of amyloid-beta (16-22) peptide. Wang, Yiming , Bunce, Samuel J. , Radford, Sheena E. , Wilson, Andrew J. , Auer, Stefan and Hall, Carol K. (2019) Proceedings of the National Academy of Sciences of the United States of America, 116, 2091-2096. doi:10.1073/pnas.1819592116
  35. Design and synthesis of cysteine-specific labels for photo-crosslinking studies. Walko, Martin , Hewitt, Eric , Radford, Sheena E. and Wilson, Andrew J. (2019) Rsc Advances, 9, 7610-7614. doi:10.1039/c8ra10436k
  36. Rapid mapping of protein interactions using tag-transfer photocrosslinkers. Horne, Jim E. , Walko, Martin , Calabrese, Antonio N. , Levenstein, Mark A. , Brockwell, David J. , Kapur, Nikil , Wilson, Andrew J. and Radford, Sheena E. (2018) Angewandte Chemie-international Edition, 57, 16688-16692. doi:10.1002/anie.201809149
  37. A new era for understanding amyloid structures and disease. Iadanza, Matthew G. , Jackson, Matthew P. , Hewitt, Eric W. , Ranson, Neil A. and Radford, Sheena E. (2018) Nature Reviews Molecular Cell Biology, 19, 755-773. doi:10.1038/s41580-018-0060-8
  38. Comparing hydrogen deuterium exchange and fast photochemical oxidation of proteins: a structural characterisation of wild-type and Delta N6 beta(2)-microglobulin. Cornwell, Owen , Radford, Sheena E. , Ashcroft, Alison E. and Ault, James R. (2018) Journal of the American Society for Mass Spectrometry, 29, 2413-2426. doi:10.1007/s13361-018-2067-y
  39. Orientation of a diagnostic ligand bound to macroscopically aligned amyloid-beta fibrils determined by solid-state NMR. Townsend, David , Hughes, Eleri , Stewart, Katie L. , Griffin, John M. , Radford, Sheena E. and Middleton, David A. (2018) Journal of Physical Chemistry Letters, 9, 6611-6615. doi:10.1021/acs.jpclett.8b02448
  40. The structure of a beta(2)-microglobulin fibril suggests a molecular basis for its amyloid polymorphism. Iadanza, Matthew G. , Silvers, Robert , Boardman, Joshua , Smith, Hugh I. , Karamanos, Theodoros K. , Debelouchina, Galia T. , Su, Yongchao , Griffin, Robert G. , Ranson, Neil A. and Radford, Sheena E. (2018) Nature Communications, 9, . doi:10.1038/s41467-018-06761-6
  41. Mass spectrometry-enabled structural biology of membrane proteins. Calabrese, Antonio N. and Radford, Sheena E. (2018) Methods, 147, 187-205. doi:10.1016/j.ymeth.2018.02.020
  42. Epigallocatechin-3-gallate remodels apolipoprotein a-i amyloid fibrils into soluble oligomers in the presence of heparin. Townsend, David , Hughes, Eleri , Akien, Geoffrey , Stewart, Katie L. , Radford, Sheena E. , Rochester, David and Middleton, David A. (2018) Journal of Biological Chemistry, 293, 12877-12893. doi:10.1074/jbc.RA118.002038
  43. A peptide-display protein scaffold to facilitate single molecule force studies of aggregation-prone peptides. Doherty, Ciaran P. A. , Young, Lydia M. , Karamanos, Theodoros K. , Smith, Hugh I. , Jackson, Matthew P. , Radford, Sheena E. and Brockwell, David J. (2018) Protein Science, 27, 1205-1217. doi:10.1002/pro.3386
  44. The role of beta-barrels 1 and 2 in the enzymatic activity of factor xiii a-subunit. Hethershaw, E. L. , Adamson, P. J. , Smith, K. A. , Goldsberry, W. N. , Pease, R. J. , Radford, S. E. , Grant, P. J. , Ariens, R. A. S. , Maurer, M. C. and Philippou, H. (2018) Journal of Thrombosis and Haemostasis, 16, 1391-1401. doi:10.1111/jth.14128
  45. Dynamic action of the sec machinery during initiation, protein translocation and termination. Fessl, Tomas , Watkins, Daniel , Oatley, Peter , Allen, William John , Corey, Robin Adam , Horne, Jim , Baldwin, Steve A. , Radford, Sheena E. , Collinson, Ian and Tuma, Roman (2018) Elife, 7, . doi:10.7554/eLife.35112
  46. Conformational flexibility within the nascent polypeptide-associated complex enables its interactions with structurally diverse client proteins. Martin, Esther M. , Jackson, Matthew P. , Gamerdinger, Martin , Gense, Karina , Karamonos, Theodoros K. , Humes, Julia R. , Deuerling, Elke , Ashcroft, Alison E. and Radford, Sheena E. (2018) Journal of Biological Chemistry, 293, 8554-8568. doi:10.1074/jbc.RA117.001568
  47. Using extensional flow to reveal diverse aggregation landscapes for three IgG1 molecules. Willis, Leon F. , Kumar, Amit , Dobson, John , Bond, Nicholas J. , Lowe, David , Turner, Richard , Radford, Sheena E. , Kapur, Nikil and Brockwell, David J. (2018) Biotechnology and Bioengineering, 115, 1216-1225. doi:10.1002/bit.26543
  48. Identification of a novel site of interaction between ataxin-3 and the amyloid aggregation inhibitor polyglutamine binding peptide 1. Knight, Patrick D. , Karamanos, Theodoros K. , Radford, Sheena E. and Ashcroft, Alison E. (2018) European Journal of Mass Spectrometry, 24, 129-140. doi:10.1177/1469066717729298
  49. Outer membrane protein folding from an energy landscape perspective. Schiffrin, Bob , Brockwell, David J. and Radford, Sheena E. (2017) Bmc Biology, 15, . doi:10.1186/s12915-017-0464-5
  50. Effects of periplasmic chaperones and membrane thickness on bama-catalyzed outer-membrane protein folding. Schiffrin, Bob , Calabrese, Antonio N. , Higgins, Anna J. , Humes, Julia R. , Ashcroft, Alison E. , Kalli, Antreas C. , Brockwell, David J. and Radford, Sheena E. (2017) Journal of Molecular Biology, 429, 3776-3792. doi:10.1016/j.jmb.2017.09.008
  51. Topological dissection of the membrane transport protein mhp1 derived from cysteine accessibility and mass spectrometry. Calabrese, Antonio N. , Jackson, Scott M. , Jones, Lynsey N. , Beckstein, Oliver , Heinkel, Florian , Gsponer, Joerg , Sharples, David , Sans, Marta , Kokkinidou, Maria , Pearson, Arwen R. , Radford, Sheena E. , Ashcroft, Alison E. and Henderson, Peter J. F. (2017) Analytical Chemistry, 89, 8844-8852. doi:10.1021/acs.analchem.7b01310
  52. Investigating the structural compaction of biomolecules upon transition to the gas-phase using esi-twims-ms. Devine, Paul W. A. , Fisher, Henry C. , Calabrese, Antonio N. , Whelan, Fiona , Higazi, Daniel R. , Potts, Jennifer R. , Lowe, David C. , Radford, Sheena E. and Ashcroft, Alison E. (2017) Journal of the American Society for Mass Spectrometry, 28, 1855-1862. doi:10.1007/s13361-017-1689-9
  53. Molecular origins of the compatibility between glycosaminoglycans and a beta 40 amyloid fibrils. Stewart, Katie L. , Hughes, Eleri , Yates, Edwin A. , Middleton, David A. and Radford, Sheena E. (2017) Journal of Molecular Biology, 429, 2449-2462. doi:10.1016/j.jmb.2017.07.003
  54. Small molecule probes of protein aggregation. Young, Lydia M. , Ashcroft, Alison E. and Radford, Sheena E. (2017) Current Opinion in Chemical Biology, 39, 90-99. doi:10.1016/j.cbpa.2017.06.008
  55. Lateral opening in the intact beta-barrel assembly machinery captured by cryo-EM. Higgins, A. J. , Iadanza, M. G. , Schiffrin, B. , Calabrese, A. N. , Humes, J. R. , Brockwell, D. J. , Ashcroft, A. E. , Ranson, N. A. and Radford, S. E. (2017) European Biophysics Journal With Biophysics Letters, 46, S346. doi:
  56. Complementary cross-linking and fluorescence studies of outer membrane protein biogenesis in vitro. Horne, J. E. , Radford, S. E. and Brockwell, D. J. (2017) European Biophysics Journal With Biophysics Letters, 46, S346. doi:
  57. Identifying the contributions of the different domains within SurA on outer member protein folding. Humes, J. R. , Higgins, A. J. , Brockwell, D. J. and Radford, S. E. (2017) European Biophysics Journal With Biophysics Letters, 46, S346. doi:
  58. The challenges and opportunities of understanding protein folding and misfolding in health and disease. Radford, S. E. (2017) European Biophysics Journal With Biophysics Letters, 46, S44. doi:
  59. Understanding co-polymerization in amyloid formation by direct observation of mixed oligomers. Young, Lydia M. , Tu, Ling-Hsien , Raleigh, Daniel P. , Ashcroft, Alison E. and Radford, Sheena E. (2017) Chemical Science, 8, 5030-5040. doi:10.1039/c7sc00620a
  60. Inducing protein aggregation by extensional flow. Dobson, John , Kumar, Amit , Willis, Leon F. , Tuma, Roman , Higazi, Daniel R. , Turner, Richard , Lowe, David C. , Ashcroft, Alison E. , Radford, Sheena E. , Kapur, Nikil and Brockwell, David J. (2017) Proceedings of the National Academy of Sciences of the United States of America, 114, 4673-4678. doi:10.1073/pnas.1702724114
  61. Fretting about outer membrane protein biogenesis. How exactly do they fold?. Horne, Jim E. , Brockwell, David J. and Radford, Sheena E. (2017) Biophysical Journal, 112, 205A. doi:10.1016/j.bpj.2016.11.1131
  62. FPOP-LC-MS-MS suggests differences in interaction sites of amphipols and detergents with outer membrane proteins. Watkinson, Thomas G. , Calabrese, Antonio N. , Ault, James R. , Radford, Sheena E. and Ashcroft, Alison E. (2017) Journal of the American Society for Mass Spectrometry, 28, 50-55. doi:10.1007/s13361-016-1421-1
  63. Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo. Dobson, Claire L. , Devine, Paul W. A. , Phillips, Jonathan J. , Higazi, Daniel R. , Lloyd, Christopher , Popovic, Bojana , Arnold, Joanne , Buchanan, Andrew , Lewis, Arthur , Goodman, Joanne , van der Walle, Christopher F. , Thornton, Peter , Vinall, Lisa , Lowne, David , Aagaard, Anna , Olsson, Lise-Lotte , Wollberg, Anna Ridderstad , Welsh, Fraser , Karamanos, Theodoros K. , Pashley, Clare L. , Iadanza, Matthew G. , Ranson, Neil A. , Ashcroft, Alison E. , Kippen, Alistair D. , Vaughan, Tristan J. , Radford, Sheena E. and Lowe, David C. (2016) Scientific Reports, 6, . doi:10.1038/srep38644
  64. Lateral opening in the intact beta-barrel assembly machinery captured by cryo-EM. Iadanza, Matthew G. , Higgins, Anna J. , Schiffrin, Bob , Calabrese, Antonio N. , Brockwell, David J. , Ashcroft, Alison E. , Radford, Sheena E. and Ranson, Neil A. (2016) Nature Communications, 7, . doi:10.1038/ncomms12865
  65. Skp is a multivalent chaperone of outer-membrane proteins. Schiffrin, Bob , Calabrese, Antonio N. , Devine, Paul W. A. , Harris, Sarah A. , Ashcroft, Alison E. , Brockwell, David J. and Radford, Sheena E. (2016) Nature Structural & Molecular Biology, 23, 786-793. doi:10.1038/nsmb.3266
  66. Atomic details of the interactions of glycosaminoglycans with amyloid-beta fibrils. Stewart, Katie L. , Hughes, Eleri , Yates, Edwin A. , Akien, Geoffrey R. , Huang, Teng-Yi , Lima, Marcelo A. , Rudd, Timothy R. , Guerrini, Marco , Hung, Shang-Cheng , Radford, Sheena E. and Middleton, David A. (2016) Journal of the American Chemical Society, 138, 8328-8331. doi:10.1021/jacs.6b02816
  67. A growing toolbox of techniques for studying beta-barrel outer membrane protein folding and biogenesis. Horne, Jim E. and Radford, Sheena E. (2016) Biochemical Society Transactions, 44, 802-809. doi:10.1042/BST20160020
  68. A population shift between sparsely populated folding intermediates determines amyloidogenicity. Karamanos, Theodoros K. , Pashley, Clare L. , Kalverda, Arnout P. , Thompson, Gary S. , Mayzel, Maxim , Orekhov, Vladislav Y. and Radford, Sheena E. (2016) Journal of the American Chemical Society, 138, 6271-6280. doi:10.1021/jacs.6b02464
  69. Two-way communication between secy and seca suggests a brownian ratchet mechanism for protein translocation. Allen, William John , Corey, Robin Adam , Oatley, Peter , Sessions, Richard Barry , Baldwin, Steve A. , Radford, Sheena E. , Tuma, Roman and Collinson, Ian (2016) Elife, 5, . doi:10.7554/eLife.15598
  70. Esi-ims-ms: a method for rapid analysis of protein aggregation and its inhibition by small molecules. Young, Lydia M. , Saunders, Janet C. , Mahood, Rachel A. , Revill, Charlotte H. , Foster, Richard J. , Ashcroft, Alison E. and Radford, Sheena E. (2016) Methods, 95, 62-69. doi:10.1016/j.ymeth.2015.05.017
  71. Comparison of the aggregation of homologous beta(2)-microglobulin variants reveals protein solubility as a key determinant of amyloid formation. Pashley, Clare L. , Hewitt, Eric W. and Radford, Sheena E. (2016) Journal of Molecular Biology, 428, 631-643. doi:10.1016/j.jmb.2016.01.009
  72. Mpul-multi: software for calculation of amyloid fibril mass per unit length from tb-tem images. Iadanza, Matthew G. , Jackson, Matthew P. , Radford, Sheena E. and Ranson, Neil A. (2016) Scientific Reports, 6, . doi:10.1038/srep21078
  73. An in vivo platform for identifying inhibitors of protein aggregation. Saunders, Janet C. , Young, Lydia M. , Mahood, Rachel A. , Jackson, Matthew P. , Revill, Charlotte H. , Foster, Richard J. , Smith, D. Alastair , Ashcroft, Alison E. , Brockwell, David J. and Radford, Sheena E. (2016) Nature Chemical Biology, 12, 94+. doi:10.1038/NCHEMBIO.1988
  74. Substrate protein folds while it is bound to the ATP-independent chaperone spy. Stull, Frederick , Koldewey, Philipp , Humes, Julia R. , Radford, Sheena E. and Bardwell, James C. A. (2016) Nature Structural & Molecular Biology, 23, 53-58. doi:10.1038/nsmb.3133
  75. Amyloid fibres: inert end-stage aggregates or key players in disease?. Tipping, Kevin W. , van Oosten-Hawle, Patricija , Hewitt, Eric W. and Radford, Sheena E. (2015) Trends in Biochemical Sciences, 40, 719-727. doi:10.1016/j.tibs.2015.10.002
  76. Systematic analysis of the use of amphipathic polymers for studies of outer membrane proteins using mass spectrometry. Watkinson, Thomas G. , Calabrese, Antonio N. , Giusti, Fabrice , Zoonens, Manuela , Radford, Sheena E. and Ashcroft, Alison E. (2015) international Journal of Mass Spectrometry, 391, 54-61. doi:10.1016/j.ijms.2015.06.017
  77. Mass spectrometric methods to analyze the structural organization of macromolecular complexes. Rajabi, Khadijeh , Ashcroft, Alison E. and Radford, Sheena E. (2015) Methods, 89, 13-21. doi:10.1016/j.ymeth.2015.03.004
  78. Using hydroxyl radical footprinting to explore the free energy landscape of protein folding. Calabrese, Antonio N. , Ault, James R. , Radford, Sheena E. and Ashcroft, Alison E. (2015) Methods, 89, 38-44. doi:10.1016/j.ymeth.2015.02.018
  79. Mechanisms of amyloid formation revealed by solution NMR. Karamanos, Theodoros K. , Kalverda, Arnout P. , Thompson, Gary S. and Radford, Sheena E. (2015) Progress in Nuclear Magnetic Resonance Spectroscopy, 88-89, 86-104. doi:10.1016/j.pnmrs.2015.05.002
  80. A comparison of the folding characteristics of free and ribosome-tethered polypeptide chains using limited proteolysis and mass spectrometry. Rajabi, Khadijeh , Reuther, Julia , Deuerling, Elke , Radford, Sheena E. and Ashcroft, Alison E. (2015) Protein Science, 24, 1282-1291. doi:10.1002/pro.2702
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“ Of experiments intended to illustrate a preconceived truth and convince people of its validity: a most venomous thing in the making of sciences; for whoever has fixed on his cause, before he has Experimented, can hardly avoid fitting his Experiment to his cause, rather than the cause to the truth of the Experiment itself. ”