Publications

  1. Structural evolution of fibril polymorphs during amyloid assembly. {Wilkinson, Martin , Xu, Yong , Thacker, Dev , Taylor, Alex,er IP , Fisher, Declan G , Gallardo, Rodrigo U , Radford, Sheena E and Ranson, Neil A} (2023) Cell, 186, 5798--5811. doi:
  2. Dynamic coupling of fast channel gating with slow ATP-turnover underpins protein transport through the sec translocon. Crossley, Joel A , Allen, William J , Watkins, Daniel W , Sabir, Tara , Radford, Sheena E , Tuma, Roman , Collinson, Ian and Fessl, Tomas (2023) the Embo Journal, , 1--13. doi:
  3. Exploring a role for flow-induced aggregation assays in platform formulation optimisation for antibody-based proteins. Willis, Leon F , Toprani, Vishal , Wijetunge, Sashini , Sievers, Annette , Lin, Laura , Williams, Jeanine , Crowley, Tom J , Radford, Sheena E , Kapur, Nikil and Brockwell, David J (2023) Journal of Pharmaceutical Sciences, , . doi:
  4. Protein--lipid charge interactions control the folding of outer membrane proteins into asymmetric membranes. Machin, Jonathan M , Kalli, Antreas C , Ranson, Neil A and Radford, Sheena E (2023) Nature Chemistry, 15, 1754--1764. doi:
  5. Mechanistic study of the conductance and enhanced single-molecule detection in a polymer-electrolyte nanopore. Marcuccio, Fabio , Soulias, Dimitrios , Chau, Chalmers C. C. , Radford, Sheena E. , Hewitt, Eric , Actis, Paolo and Edwards, Martin Andrew (2023) ACS Nanoscience Au, 3, 172-181. doi:10.1021/acsnanoscienceau.2c00050
  6. Disease-relevant β2-microglobulin variants share a common amyloid fold. Wilkinson, Martin , Gallardo, Rodrigo U. , Martinez, Roberto Maya , Guthertz, Nicolas , So, Masatomo , Aubrey, Liam D. , Radford, Sheena E. and Ranson, Neil A. (2023) Nature Communications, 14, . doi:10.1038/s41467-023-36791-8
  7. Changing shape of molecules. Radford, Sheena E. and Summers, Michael F. (2023) Journal of Molecular Biology, 435, . doi:
  8. The in-tissue molecular architecture of beta-amyloid pathology in the mammalian brain. Leistner, Conny , Wilkinson, Martin , Burgess, Ailidh , Lovatt, Megan , Goodbody, Stanley , Xu, Yong , Deuchars, Susan , Radford, Sheena E. , Ranson, Neil A. and Frank, Rene A. W. (2023) Nature Communications, 14, . doi:10.1038/s41467-023-38495-5
  9. Single-molecule fluorescence: elucidating ATP driven protein transport in the Sec complex. Crossley, Joel A. , Fessl, Tomas , Collinson, Ian , Tuma, Roman and Radford, Sheena E. (2023) Biophysical Journal, 122, 50A. doi:
  10. The delivery complex in outer membrane protein biogenesis: how the SurA chaperone interacts with the BAM enzyme. Horne, Jim E. , Fenn, Katherine , Crossley, Joel A. , Radford, Sheena E. and Ranson, Neil A. (2023) Biophysical Journal, 122, 343A. doi:
  11. Darobactin B stabilises a lateral-closed conformation of the BAM complex in E. coli cells. Haysom, Samuel F. , Machin, Jonathan , Whitehouse, James M. , Horne, Jim E. , Fenn, Katherine , Ma, Yue , El Mkami, Hassane , Boehringer, Nils , Schaeberle, Till F. , Ranson, Neil A. , Radford, Sheena E. and Pliotas, Christos (2023) Angewandte Chemie-international Edition, , . doi:10.1002/anie.202218783
  12. Taking charge: metal ions accelerate amyloid aggregation in sequence variants of alpha-synuclein. Byrd, Emily J. , Wilkinson, Martin , Radford, Sheena E. and Sobott, Frank (2023) Journal of the American Society for Mass Spectrometry, 34, 493-504. doi:10.1021/jasms.2c00379
  13. Controlling amyloid formation of intrinsically disordered proteins and peptides: slowing down or speeding up?. Xu, Yong , Maya-Martinez, Roberto and Radford, Sheena E. (2022) Essays in Biochemistry, 66, 959-975. doi:10.1042/EBC20220046
  14. Dimers of D76N-beta 2-microglobulin display potent antiamyloid aggregation activity. Maya-Martinez, Roberto , Xu, Yong , Guthertz, Nicolas , Walko, Martin , Karamanos, Theodoros K. , Sobott, Frank , Breeze, Alex,er L. and Radford, Sheena E. (2022) Journal of Biological Chemistry, 298, . doi:10.1016/j.jbc.2022.102659
  15. Probing RNA conformations using a polymer-electrolyte solid-state nanopore. Chau, Chalmers , Marcuccio, Fabio , Soulias, Dimitrios , Edwards, Martin Andrew , Tuplin, Andrew , Radford, Sheena E. , Hewitt, Eric and Actis, Paolo (2022) ACS Nano, 16, 20075-20085. doi:10.1021/acsnano.2c08312
  16. Single residue modulators of amyloid formation in the N-terminal p1-region of alpha-synuclein. Ulamec, Sabine M. , Maya-Martinez, Roberto , Byrd, Emily J. , Dewison, Katherine M. , Xu, Yong , Willis, Leon F. , Sobott, Frank , Heath, George R. , Hawle, Patricija van Oosten , Buchman, Vladimir L. , Radford, Sheena E. and Brockwell, David J. (2022) Nature Communications, 13, . doi:10.1038/s41467-022-32687-1
  17. Sequence grammar underlying the unfolding and phase separation of globular proteins. Ruff, Kiersten M. , Choi, Yoon Hee , Cox, Dezerae , Ormsby, Angelique R. , Myung, Yoochan , Ascher, David B. , Radford, Sheena E. , V. Pappu, Rohit and Hatters, Danny M. (2022) Molecular Cell, 82, 3193+. doi:10.1016/j.molcel.2022.06.024
  18. The effect of mutation on an aggregation-prone protein: an in vivo, in vitro, and in silico analysis. Guthertz, N. , van Der Kant, R. , Martinez, R. M. , Xu, Y. , Trinh, C. , Iorga, B. I. , Rousseau, F. , Schymkowitz, J. , Brockwell, D. J. and Radford, S. E. (2022) Proceedings of the National Academy of Sciences of the United States of America, 119, . doi:10.1073/pnas.2200468119
  19. Trigger factor both holds and folds its client proteins. Wu, Kevin , Minshull, Thomas C. , Radford, Sheena E. , Calabrese, Antonio N. and Bardwell, James C. A. (2022) Nature Communications, 13, . doi:10.1038/s41467-022-31767-6
  20. Dynamic interplay between the periplasmic chaperone SurA and the BAM complex in outer membrane protein folding. Schiffrin, Bob , Machin, Jonathan M. , Karamanos, Theodoros K. , Zhuravleva, Anastasia , Brockwell, David J. , Radford, Sheena E. and Calabrese, Antonio N. (2022) Communications Biology, 5, . doi:10.1038/s42003-022-03502-w
  21. High-throughput directed evolution: a golden era for protein science. McLure, Romany J. , Radford, Sheena E. and Brockwell, David J. (2022) Trends in Chemistry, 4, 378-391. doi:10.1016/j.trechm.2022.02.004
  22. Generating ensembles of dynamic misfolding proteins. Karamanos, Theodoros K. , Kalverda, Arnout P. and Radford, Sheena E. (2022) Frontiers in Neuroscience, 16, . doi:10.3389/fnins.2022.881534
  23. Roll out the barrel! Outer membrane tension resolves an unexpected folding intermediate. Horne, Jim E. and Radford, Sheena E. (2022) Cell, 185, 1107-1109. doi:10.1016/j.cell.2022.03.001
  24. Tuning the rate of aggregation of hiapp into amyloid using small-molecule modulators of assembly. Xu, Yong, Maya-Martinez, Roberto, Guthertz, Nicolas, Heath, George R., Manfield, Iain W., Breeze, Alex,er L., Sobott, Frank, Foster, Richard and Radford, Sheena E. (2022) Nature Communications, 13, . doi:10.1038/s41467-022-28660-7
  25. Global proteotoxicity caused by human beta(2) microglobulin variants impairs the unfolded protein response in C. elegans. Good, Sarah C. , Dewison, Katherine M. , Radford, Sheena E. and van Oosten-Hawle, Patricija (2021) international Journal of Molecular Sciences, 22, . doi:10.3390/ijms221910752
  26. Alphafold: a special issue and a special time for protein science. Serpell, Louise C. , Radford, Sheena E. and Otzen, Daniel E. (2021) Journal of Molecular Biology, 433, . doi:
  27. The role of membrane destabilisation and protein dynamics in bam catalysed omp folding. White, Paul , Haysom, Samuel F. , Iadanza, Matthew G. , Higgins, Anna J. , Machin, Jonathan M. , Whitehouse, James M. , Horne, Jim E. , Schiffrin, Bob , Carpenter-Platt, Charlotte , Calabrese, Antonio N. , Storek, Kelly M. , Rutherford, Steven T. , Brockwell, David J. , Ranson, Neil A. and Radford, Sheena E. (2021) Nature Communications, 12, . doi:10.1038/s41467-021-24432-x
  28. Finding the sweet spot for chaperone activity. Radford, Sheena E. and Karamanos, Theodoros K. (2021) Nature Chemistry, 13, 397-399. doi:10.1038/s41557-021-00691-5
  29. Brazilin removes toxic alpha-synuclein and seeding competent assemblies from parkinson brain by altering conformational equilibrium. Nahass, George R. , Sun, Yuanzi , Xu, Yong , Batchelor, Mark , Reilly, Madeleine , Benilova, Iryna , Kedia, Niraja , Spehar, Kevin , Sobott, Frank , Sessions, Richard B. , Caughey, Byron , Radford, Sheena E. , Jat, Parmjit S. , Collinge, John and Bieschke, Jan (2021) Journal of Molecular Biology, 433, . doi:10.1016/j.jmb.2021.166878
  30. De novo design of transmembrane beta barrels. Vorobieva, Anastassia A. , White, Paul , Liang, Binyong , Horne, Jim E. , Bera, Asim K. , Chow, Cameron M. , Gerben, Stacey , Marx, Sinduja , Kang, Alex , Stiving, Alyssa Q. , Harvey, Sophie R. , Marx, Dagan C. , Khan, G. Nasir , Fleming, Karen G. , Wysocki, Vicki H. , Brockwell, David J. , Tamm, Lukas K. , Radford, Sheena E. and Baker, David (2021) Science, 371, 801+. doi:10.1126/science.abc8182
  31. Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for Type II diabetes. Milardi, Danilo , Gazit, Ehud , Radford, Sheena E. , Xu, Yong , Gallardo, Rodrigo U. , Caflisch, Amedeo , Westermark, Gunilla T. , Westermark, Per , La Rosa, Carmelo and Ramamoorthy, Ayyalusamy (2021) Chemical Reviews, 121, 1845-1893. doi:10.1021/acs.chemrev.0c00981
  32. Investigation of D76N beta(2)-microglobulin using protein footprinting and structural mass spectrometry. Cornwell, Owen , Ault, James R. , Bond, Nicholas J. , Radford, Sheena E. and Ashcroft, Alison E. (2021) Journal of the American Society for Mass Spectrometry, 32, 1583-1592. doi:10.1021/jasms.0c00438
  33. Visualizing and trapping transient oligomers in amyloid assembly pathways. Cawood, Emma E. , Karamanos, Theodoros K. , Wilson, Andrew J. and Radford, Sheena E. (2021) Biophysical Chemistry, 268, . doi:10.1016/j.bpc.2020.106505
  34. Modulation of amyloidogenic protein self-assembly using tethered small molecules. Cawood, Emma E. , Guthertz, Nicolas , Ebo, Jessica S. , Karamanos, Theodoros K. , Radford, Sheena E. and Wilson, Andrew J. (2020) Journal of the American Chemical Society, 142, 20845-20854. doi:10.1021/jacs.0c10629
  35. Distortion of the bilayer and dynamics of the BAM complex in lipid nanodiscs. Iadanza, Matthew G. , Schiffrin, Bob , White, Paul , Watson, Matthew A. , Horne, Jim E. , Higgins, Anna J. , Calabrese, Antonio N. , Brockwell, David J. , Tuma, Roman , Kalli, Antreas C. , Radford, Sheena E. and Ranson, Neil A. (2020) Communications Biology, 3, . doi:10.1038/s42003-020-01419-w
  36. Looking beyond the core: the role of flanking regions in the aggregation of amyloidogenic peptides and proteins. Ulamec, Sabine M. , Brockwell, David J. and Radford, Sheena E. (2020) Frontiers in Neuroscience, 14, . doi:10.3389/fnins.2020.611285
  37. Modulation of beta-amyloid fibril formation in Alzheimer's disease by microglia and infection. Brown, Madeleine R. , Radford, Sheena E. and Hewitt, Eric W. (2020) Frontiers in Molecular Neuroscience, 13, . doi:10.3389/fnmol.2020.609073
  38. Structural insights into peptide self-assembly using photo-induced crosslinking experiments and discontinuous molecular dynamics. Bunce, Samuel J. , Wang, Yiming , Radford, Sheena E. , Wilson, Andrew J. and Hall, Carol K. (2020) Aiche Journal, , . doi:10.1002/aic.17101
  39. The uniqueness of flow in probing the aggregation behavior of clinically relevant antibodies. Willis, Leon F. , Kumar, Amit , Jain, Tushar , Caffrey, Isabelle , Xu, Yingda , Radford, Sheena E. , Kapur, Nikil , Vasquez, Maximiliano and Brockwell, David J. (2020) Engineering Reports, 27, 1094. doi:10.1002/eng2.12147
  40. Fibril structures of diabetes-related amylin variants reveal a basis for surface-templated assembly. Gallardo, Rodrigo , Iadanza, Matthew G. , Xu, Yong , Heath, George R. , Foster, Richard , Radford, Sheena E. and Ranson, Neil A. (2020) Nature Structural & Molecular Biology, 27, 1094. doi:10.1038/s41594-020-00525-x, Early Access Date = OCT 2020
  41. Potential human transmission of amyloid beta pathology: surveillance and risks. Lauwers, Elsa , Lalli, Giovanna , Br,ner, Sebastian , Collinge, John , Compernolle, Veerle , Duyckaerts, Charles , Edgren, Gustaf , Haik, Stephane , Hardy, John , Helmy, Adel , Ivinson, Adrian J. , Jaunmuktane, Zane , Jucker, Mathias , Knight, Richard , Lemmens, Robin , Lin, I-Chun , Love, Seth , Mead, Simon , Perry, V. Hugh , Pickett, James , Poppy, Guy , Radford, Sheena E. , Rousseau, Frederic , Routledge, Carol , Schiavo, Giampietro , Schymkowitz, Joost , Selkoe, Dennis J. , Smith, Colin , Thal, Dietmar R. , Theys, Tom , Tiberghien, Pierre , van den Burg, Peter , V,ekerckhove, Philippe , Walton, Clare , Zaaijer, Hans L. , Zetterberg, Henrik and De Strooper, Bart (2020) Lancet Neurology, 19, 872-878. doi:
  42. The role of the IT-state in D76N beta(2)-microglobulin amyloid assembly: a crucial intermediate or an innocuous bystander?. Smith, I, Hugh , Guthertz, Nicolas , Cawood, Emma E. , Maya-Martinez, Roberto , Breeze, Alex,er L. and Radford, Sheena E. (2020) Journal of Biological Chemistry, 295, 12474-12484. doi:10.1074/jbc.RA120.014901
  43. Spot the difference: function versus toxicity in amyloid fibrils. Ulamec, Sabine M. and Radford, Sheena E. (2020) Trends in Biochemical Sciences, 45, 635-636. doi:10.1016/j.tibs.2020.04.007
  44. Role of the lipid bilayer in outer membrane protein folding in gram-negative bacteria. Horne, Jim E. , Brockwell, David J. and Radford, Sheena E. (2020) Journal of Biological Chemistry, 295, 10340-10367. doi:10.1074/jbc.REV120.011473
  45. Macromolecular crowding enhances the detection of DNA and proteins by a solid-state nanopore. Chau, Chalmers C. , Radford, Sheena E. , Hewitt, Eric W. and Actis, Paolo (2020) Nano Letters, 20, 5553-5561. doi:10.1021/acs.nanolett.0c02246
  46. Pyxlinkviewer: a flexible tool for visualization of protein chemical crosslinking data within thepymolmolecular graphics system. Schiffrin, Bob , Radford, Sheena E. , Brockwell, David J. and Calabrese, Antonio N. (2020) Protein Science, 29, 1851-1857. doi:10.1002/pro.3902, Early Access Date = JUL 2020
  47. Structural insight into the formation of lipoprotein-beta-barrel complexes. Rodriguez-Alonso, Raquel , Letoquart, Juliette , Van Son Nguyen , Louis, Gwennaelle , Calabrese, Antonio N. , Iorga, Bogdan I. , Radford, Sheena E. , Cho, Seung-Hyun , Remaut, Han and Collet, Jean-Francois () Nature Chemical Biology, , . doi:10.1038/s41589-020-0575-0, Early Access Date = JUN 2020
  48. Inter-domain dynamics in the chaperone SurA and multi-site binding to its outer membrane protein clients. Calabrese, Antonio N. , Schiffrin, Bob , Watson, Matthew , Karamanos, Theodoros K. , Walko, Martin , Humes, Julia R. , Horne, Jim E. , White, Paul , Wilson, Andrew J. , Kalli, Antreas C. , Tuma, Roman , Ashcroft, Alison E. , Brockwell, David J. and Radford, Sheena E. (2020) Nature Communications, 11, . doi:10.1038/s41467-020-15702-1
  49. An in vivo platform to select and evolve aggregation-resistant proteins. Ebo, Jessica S. , Saunders, Janet C. , Devine, Paul W. A. , Gordon, Alice M. , Warwick, Amy S. , Schiffrin, Bob , Chin, Stacey E. , Engl,, Elizabeth , Button, James D. , Lloyd, Christopher , Bond, Nicholas J. , Ashcroft, Alison E. , Radford, Sheena E. , Lowe, David C. and Brockwell, David J. (2020) Nature Communications, 11, . doi:10.1038/s41467-020-15667-1
  50. A short motif in the N-terminal region of alpha-synuclein is critical for both aggregation and function. Doherty, Ciaran P. A. , Ulamec, Sabine M. , Maya-Martinez, Roberto , Good, Sarah C. , Makepeace, Jemma , Khan, G. Nasir , van Oosten-Hawle, Patricija , Radford, Sheena E. and Brockwell, David J. (2020) Nature Structural & Molecular Biology, 27, 249+. doi:10.1038/s41594-020-0384-x
  51. Amyloid structures: much more than just a cross-beta fold. Gallardo, Rodrigo , Ranson, Neil A. and Radford, Sheena E. (2020) Current Opinion in Structural Biology, 60, 7-16. doi:10.1016/j.sbi.2019.09.001
  52. Using protein engineering to understand and modulate aggregation. Ebo, Jessica S. , Guthertz, Nicolas , Radford, Sheena E. and Brockwell, David J. (2020) Current Opinion in Structural Biology, 60, 157-166. doi:10.1016/j.sbi.2020.01.005
  53. Collagen I weakly interacts with the beta-sheets of beta(2)-microglobulin and enhances conformational exchange to induce amyloid formation. Hoop, Cody L. , Zhu, Jie , Bhattacharya, Shibani , Tobita, Caitlyn A. , Radford, Sheena E. and Baum, Jean (2020) Journal of the American Chemical Society, 142, 1321-1331. doi:10.1021/jacs.9b10421
  54. Homage to Chris Dobson. Baum, Jean , Chiti, Fabrizio , De Simone, Alfonso , Knowles, Tuomas P. J. , Kumita, Janet R. , Radford, Sheena E. , Robinson, Carol V. , Salvatella, Xavier , Valelli, Karen , Vendruscolo, Michele , Pastore, Annalisa and Tartaglia, Gian Gaetano (2019) Frontiers in Molecular Biosciences, 6, . doi:10.3389/fmolb.2019.00137
  55. Long-range conformational changes in monoclonal antibodies revealed using FPOP-LS-MS/MS. Cornwell, Owen , Bond, Nicholas J. , Radford, Sheena E. and Ashcroft, Alison E. (2019) Analytical Chemistry, 91, 15163-15170. doi:10.1021/acs.analchem.9b03958
  56. Structural mapping of oligomeric intermediates in an amyloid assembly pathway. Karamanos, Theodoros K. , Jackson, Matthew P. , Calabrese, Antonio N. , Goodchild, Sophia C. , Cawood, Emma E. , Section, Gary S. Thompson , Kalverda, Arnout P. , Hewitt, Eric W. and Radford, Sheena E. (2019) Elife, 8, . doi:10.7554/eLife.46574
  57. Extracellular matrix components modulate different stages in (2)-microglobulin amyloid formation. Benseny-Cases, Nuria , Karamanos, Theodoros K. , Hoop, Cody L. , Baum, Jean and Radford, Sheena E. (2019) Journal of Biological Chemistry, 294, 9392-9401. doi:10.1074/jbc.RA119.008300
  58. Molecular insights into the surface-catalyzed secondary nucleation of amyloid-beta(40) (a beta(40)) by the peptide fragment a beta(16-22). Bunce, Samuel J. , Wang, Yiming , Stewart, Katie L. , Ashcroft, Alison E. , Radford, Sheena E. , Hall, Carol K. and Wilson, Andrew J. (2019) Science Advances, 5, . doi:10.1126/sciadv.aav8216
  59. Dual role of ribosome-binding domain of nac as a potent suppressor of protein aggregation and aging-related proteinopathies. Shen, Koning , Gamerdinger, Martin , Chan, Rebecca , Gense, Karina , Martin, Esther M. , Sachs, Nadine , Knight, Patrick D. , Schloemer, Renate , Calabrese, Antonio N. , Stewart, Katie L. , Leiendecker, Lukas , Baghel, Ankit , Radford, Sheena E. , Frydman, Judith and Deuerling, Elke (2019) Molecular Cell, 74, 729+. doi:10.1016/j.molcel.2019.03.012
  60. The role of SurA pplase domains in preventing aggregation of the outer-membrane proteins tOmpA and OmpT. Humes, Julia R. , Schiffrin, Bob , Calabrese, Antonio N. , Higgins, Anna J. , Westhead, David R. , Brockwell, David J. and Radford, Sheena E. (2019) Journal of Molecular Biology, 431, 1267-1283. doi:10.1016/j.jmb.2019.01.032
  61. Thermodynamic phase diagram of amyloid-beta (16-22) peptide. Wang, Yiming , Bunce, Samuel J. , Radford, Sheena E. , Wilson, Andrew J. , Auer, Stefan and Hall, Carol K. (2019) Proceedings of the National Academy of Sciences of the United States of America, 116, 2091-2096. doi:10.1073/pnas.1819592116
  62. Design and synthesis of cysteine-specific labels for photo-crosslinking studies. Walko, Martin , Hewitt, Eric , Radford, Sheena E. and Wilson, Andrew J. (2019) Rsc Advances, 9, 7610-7614. doi:10.1039/c8ra10436k
  63. Rapid mapping of protein interactions using tag-transfer photocrosslinkers. Horne, Jim E. , Walko, Martin , Calabrese, Antonio N. , Levenstein, Mark A. , Brockwell, David J. , Kapur, Nikil , Wilson, Andrew J. and Radford, Sheena E. (2018) Angewandte Chemie-international Edition, 57, 16688-16692. doi:10.1002/anie.201809149
  64. A new era for understanding amyloid structures and disease. Iadanza, Matthew G. , Jackson, Matthew P. , Hewitt, Eric W. , Ranson, Neil A. and Radford, Sheena E. (2018) Nature Reviews Molecular Cell Biology, 19, 755-773. doi:10.1038/s41580-018-0060-8
  65. Comparing hydrogen deuterium exchange and fast photochemical oxidation of proteins: a structural characterisation of wild-type and Delta N6 beta(2)-microglobulin. Cornwell, Owen , Radford, Sheena E. , Ashcroft, Alison E. and Ault, James R. (2018) Journal of the American Society for Mass Spectrometry, 29, 2413-2426. doi:10.1007/s13361-018-2067-y
  66. Orientation of a diagnostic ligand bound to macroscopically aligned amyloid-beta fibrils determined by solid-state NMR. Townsend, David , Hughes, Eleri , Stewart, Katie L. , Griffin, John M. , Radford, Sheena E. and Middleton, David A. (2018) Journal of Physical Chemistry Letters, 9, 6611-6615. doi:10.1021/acs.jpclett.8b02448
  67. The structure of a beta(2)-microglobulin fibril suggests a molecular basis for its amyloid polymorphism. Iadanza, Matthew G. , Silvers, Robert , Boardman, Joshua , Smith, Hugh I. , Karamanos, Theodoros K. , Debelouchina, Galia T. , Su, Yongchao , Griffin, Robert G. , Ranson, Neil A. and Radford, Sheena E. (2018) Nature Communications, 9, . doi:10.1038/s41467-018-06761-6
  68. Mass spectrometry-enabled structural biology of membrane proteins. Calabrese, Antonio N. and Radford, Sheena E. (2018) Methods, 147, 187-205. doi:10.1016/j.ymeth.2018.02.020
  69. Epigallocatechin-3-gallate remodels apolipoprotein a-i amyloid fibrils into soluble oligomers in the presence of heparin. Townsend, David , Hughes, Eleri , Akien, Geoffrey , Stewart, Katie L. , Radford, Sheena E. , Rochester, David and Middleton, David A. (2018) Journal of Biological Chemistry, 293, 12877-12893. doi:10.1074/jbc.RA118.002038
  70. A peptide-display protein scaffold to facilitate single molecule force studies of aggregation-prone peptides. Doherty, Ciaran P. A. , Young, Lydia M. , Karamanos, Theodoros K. , Smith, Hugh I. , Jackson, Matthew P. , Radford, Sheena E. and Brockwell, David J. (2018) Protein Science, 27, 1205-1217. doi:10.1002/pro.3386
  71. The role of beta-barrels 1 and 2 in the enzymatic activity of factor xiii a-subunit. Hethershaw, E. L. , Adamson, P. J. , Smith, K. A. , Goldsberry, W. N. , Pease, R. J. , Radford, S. E. , Grant, P. J. , Ariens, R. A. S. , Maurer, M. C. and Philippou, H. (2018) Journal of Thrombosis and Haemostasis, 16, 1391-1401. doi:10.1111/jth.14128
  72. Dynamic action of the sec machinery during initiation, protein translocation and termination. Fessl, Tomas , Watkins, Daniel , Oatley, Peter , Allen, William John , Corey, Robin Adam , Horne, Jim , Baldwin, Steve A. , Radford, Sheena E. , Collinson, Ian and Tuma, Roman (2018) Elife, 7, . doi:10.7554/eLife.35112
  73. Conformational flexibility within the nascent polypeptide-associated complex enables its interactions with structurally diverse client proteins. Martin, Esther M. , Jackson, Matthew P. , Gamerdinger, Martin , Gense, Karina , Karamonos, Theodoros K. , Humes, Julia R. , Deuerling, Elke , Ashcroft, Alison E. and Radford, Sheena E. (2018) Journal of Biological Chemistry, 293, 8554-8568. doi:10.1074/jbc.RA117.001568
  74. Using extensional flow to reveal diverse aggregation landscapes for three IgG1 molecules. Willis, Leon F. , Kumar, Amit , Dobson, John , Bond, Nicholas J. , Lowe, David , Turner, Richard , Radford, Sheena E. , Kapur, Nikil and Brockwell, David J. (2018) Biotechnology and Bioengineering, 115, 1216-1225. doi:10.1002/bit.26543
  75. Identification of a novel site of interaction between ataxin-3 and the amyloid aggregation inhibitor polyglutamine binding peptide 1. Knight, Patrick D. , Karamanos, Theodoros K. , Radford, Sheena E. and Ashcroft, Alison E. (2018) European Journal of Mass Spectrometry, 24, 129-140. doi:10.1177/1469066717729298
  76. Outer membrane protein folding from an energy landscape perspective. Schiffrin, Bob , Brockwell, David J. and Radford, Sheena E. (2017) Bmc Biology, 15, . doi:10.1186/s12915-017-0464-5
  77. Effects of periplasmic chaperones and membrane thickness on bama-catalyzed outer-membrane protein folding. Schiffrin, Bob , Calabrese, Antonio N. , Higgins, Anna J. , Humes, Julia R. , Ashcroft, Alison E. , Kalli, Antreas C. , Brockwell, David J. and Radford, Sheena E. (2017) Journal of Molecular Biology, 429, 3776-3792. doi:10.1016/j.jmb.2017.09.008
  78. Topological dissection of the membrane transport protein mhp1 derived from cysteine accessibility and mass spectrometry. Calabrese, Antonio N. , Jackson, Scott M. , Jones, Lynsey N. , Beckstein, Oliver , Heinkel, Florian , Gsponer, Joerg , Sharples, David , Sans, Marta , Kokkinidou, Maria , Pearson, Arwen R. , Radford, Sheena E. , Ashcroft, Alison E. and Henderson, Peter J. F. (2017) Analytical Chemistry, 89, 8844-8852. doi:10.1021/acs.analchem.7b01310
  79. Investigating the structural compaction of biomolecules upon transition to the gas-phase using esi-twims-ms. Devine, Paul W. A. , Fisher, Henry C. , Calabrese, Antonio N. , Whelan, Fiona , Higazi, Daniel R. , Potts, Jennifer R. , Lowe, David C. , Radford, Sheena E. and Ashcroft, Alison E. (2017) Journal of the American Society for Mass Spectrometry, 28, 1855-1862. doi:10.1007/s13361-017-1689-9
  80. Molecular origins of the compatibility between glycosaminoglycans and a beta 40 amyloid fibrils. Stewart, Katie L. , Hughes, Eleri , Yates, Edwin A. , Middleton, David A. and Radford, Sheena E. (2017) Journal of Molecular Biology, 429, 2449-2462. doi:10.1016/j.jmb.2017.07.003
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