Publications

  1. Protein-lipid charge interactions control the folding of outer membrane proteins into asymmetric membranes. {Machin, Jonathan M. , Kalli, Antreas C. , Ranson, Neil A. and Radford, Sheena E.} (2023) Nature Chemistry, 15, 1754+. doi:10.1038/s41557-023-01319-6
  2. Substitution of Met-38 to Ile in γ- synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid. Aubrey, Liam D. , Ninkina, Natalia , Ulamec, Sabine M. , Abramycheva, Natalia Y. , Vasili, Eftychia , Devine, Oliver M. , Wilkinson, Martin , Mackinnon, Eilish , Limorenko, Galina , Walko, Martin , Muwanga, Sarah , Amadio, Leonardo , Peters, Owen M. , Illarioshkin, Sergey N. , Outeiro, Tiago F. , Ranson, Neil A. , Brockwell, David J. , Buchman, Vladimir L. and Radford, Sheena E. (2024) Proceedings of the National Academy of Sciences of the United States of America, 121, . doi:10.1073/pnas.2309700120
  3. Local structural preferences in shaping tau amyloid polymorphism. Louros, Nikolaos , Wilkinson, Martin , Tsaka, Grigoria , Ramakers, Meine , Morelli, Chiara , Garcia, Teresa , Gallardo, Rodrigo , D'Haeyer, Sam , Goossens, Vera , Audenaert, Dominique , Thal, Dietmar Rudolf , Mackenzie, Ian R. , Rademakers, Rosa , Ranson, Neil A. , Radford, Sheena E. , Rousseau, Frederic and Schymkowitz, Joost (2024) Nature Communications, 15, . doi:10.1038/s41467-024-45429-2
  4. A targetable N-terminal motif orchestrates α-synuclein oligomer-to-fibril conversion. Santos, Jaime , Cuellar, Jorge , Pallares, Irantzu , Byrd, Emily J. , Lends, Alons , Moro, Fern,o , Abdul-Shukkoor, Muhammed Bilal , Pujols, Jordi , Velasco-Carneros, Lorea , Sobott, Frank , Otzen, Daniel E. , Calabrese, Antonio N. , Muga, Arturo , Pedersen, Jan Skov , Loquet, Antoine , Valpuesta, Jose Maria , Radford, Sheena E. and Ventura, Salvador (2024) Journal of the American Chemical Society, 146, 12702-12711. doi:10.1021/jacs.4c02262
  5. Outer membrane protein assembly mediated by BAM-SurA complexes. Fenn, Katherine L. , Horne, Jim E. , Crossley, Joel A. , Bohringer, Nils , Horne, Romany J. , Schaberle, Till F. , Calabrese, Antonio N. , Radford, Sheena E. and Ranson, Neil A. (2024) Nature Communications, 15, . doi:10.1038/s41467-024-51358-x
  6. Structural evolution of fibril polymorphs during amyloid assembly. Wilkinson, Martin , Xu, Yong , Thacker, Dev , Fisher, Declan G. , Taylor, Alex,er I. P. , Gallardo, Rodrigo U. , Radford, Sheena E. and Ranson, Neil A. (2023) Cell, 186, . doi:10.1016/j.cell.2023.11.025
  7. Dynamic coupling of fast channel gating with slow ATP-turnover underpins protein transport through the Sec translocon. Crossley, Joel A. , Allen, William J. , Watkins, Daniel W. , Sabir, Tara , Radford, Sheena E. , Tuma, Roman , Collinson, Ian and Fessl, Tomas (2024) Embo Journal, 43, 1-13. doi:10.1038/s44318-023-00004-1
  8. Exploring a role for flow-induced aggregation assays in platform formulation optimisation for antibody-based proteins. Willis, Leon F. , Toprani, Vishal , Wijetunge, Sashini , Sievers, Annette , Lin, Laura , Williams, Jeanine , Crowley, Tom J. , Radford, Sheena E. , Kapur, Nikil and Brockwell, David J. (2024) Journal of Pharmaceutical Sciences, 113, 625-636. doi:10.1016/j.xphs.2023.10.031
  9. Mechanistic study of the conductance and enhanced single-molecule detection in a polymer-electrolyte nanopore. Marcuccio, Fabio , Soulias, Dimitrios , Chau, Chalmers C. C. , Radford, Sheena E. , Hewitt, Eric , Actis, Paolo and Edwards, Martin Andrew (2023) ACS Nanoscience Au, 3, 172-181. doi:10.1021/acsnanoscienceau.2c00050
  10. Disease-relevant β2-microglobulin variants share a common amyloid fold. Wilkinson, Martin , Gallardo, Rodrigo U. , Martinez, Roberto Maya , Guthertz, Nicolas , So, Masatomo , Aubrey, Liam D. , Radford, Sheena E. and Ranson, Neil A. (2023) Nature Communications, 14, . doi:10.1038/s41467-023-36791-8
  11. Changing shape of molecules. Radford, Sheena E. and Summers, Michael F. (2023) Journal of Molecular Biology, 435, . doi:10.1016/j.jmb.2023.168092
  12. The in-tissue molecular architecture of beta-amyloid pathology in the mammalian brain. Leistner, Conny , Wilkinson, Martin , Burgess, Ailidh , Lovatt, Megan , Goodbody, Stanley , Xu, Yong , Deuchars, Susan , Radford, Sheena E. , Ranson, Neil A. and Frank, Rene A. W. (2023) Nature Communications, 14, . doi:10.1038/s41467-023-38495-5
  13. Single-molecule fluorescence: elucidating ATP driven protein transport in the Sec complex. Crossley, Joel A. , Fessl, Tomas , Collinson, Ian , Tuma, Roman and Radford, Sheena E. (2023) Biophysical Journal, 122, 50A. doi:
  14. The delivery complex in outer membrane protein biogenesis: how the SurA chaperone interacts with the BAM enzyme. Horne, Jim E. , Fenn, Katherine , Crossley, Joel A. , Radford, Sheena E. and Ranson, Neil A. (2023) Biophysical Journal, 122, 343A. doi:
  15. Darobactin B stabilises a lateral-closed conformation of the BAM complex in E. coli cells. Haysom, Samuel F. , Machin, Jonathan , Whitehouse, James M. , Horne, Jim E. , Fenn, Katherine , Ma, Yue , El Mkami, Hassane , Boehringer, Nils , Schaeberle, Till F. , Ranson, Neil A. , Radford, Sheena E. and Pliotas, Christos (2023) Angewandte Chemie-international Edition, , . doi:10.1002/anie.202218783
  16. Taking charge: metal ions accelerate amyloid aggregation in sequence variants of alpha-synuclein. Byrd, Emily J. , Wilkinson, Martin , Radford, Sheena E. and Sobott, Frank (2023) Journal of the American Society for Mass Spectrometry, 34, 493-504. doi:10.1021/jasms.2c00379
  17. Controlling amyloid formation of intrinsically disordered proteins and peptides: slowing down or speeding up?. Xu, Yong , Maya-Martinez, Roberto and Radford, Sheena E. (2022) Essays in Biochemistry, 66, 959-975. doi:10.1042/EBC20220046
  18. Dimers of D76N-beta 2-microglobulin display potent antiamyloid aggregation activity. Maya-Martinez, Roberto , Xu, Yong , Guthertz, Nicolas , Walko, Martin , Karamanos, Theodoros K. , Sobott, Frank , Breeze, Alex,er L. and Radford, Sheena E. (2022) Journal of Biological Chemistry, 298, . doi:10.1016/j.jbc.2022.102659
  19. Probing RNA conformations using a polymer-electrolyte solid-state nanopore. Chau, Chalmers , Marcuccio, Fabio , Soulias, Dimitrios , Edwards, Martin Andrew , Tuplin, Andrew , Radford, Sheena E. , Hewitt, Eric and Actis, Paolo (2022) ACS Nano, 16, 20075-20085. doi:10.1021/acsnano.2c08312
  20. Single residue modulators of amyloid formation in the N-terminal p1-region of alpha-synuclein. Ulamec, Sabine M. , Maya-Martinez, Roberto , Byrd, Emily J. , Dewison, Katherine M. , Xu, Yong , Willis, Leon F. , Sobott, Frank , Heath, George R. , Hawle, Patricija van Oosten , Buchman, Vladimir L. , Radford, Sheena E. and Brockwell, David J. (2022) Nature Communications, 13, . doi:10.1038/s41467-022-32687-1
  21. Sequence grammar underlying the unfolding and phase separation of globular proteins. Ruff, Kiersten M. , Choi, Yoon Hee , Cox, Dezerae , Ormsby, Angelique R. , Myung, Yoochan , Ascher, David B. , Radford, Sheena E. , V. Pappu, Rohit and Hatters, Danny M. (2022) Molecular Cell, 82, 3193+. doi:10.1016/j.molcel.2022.06.024
  22. The effect of mutation on an aggregation-prone protein: an in vivo, in vitro, and in silico analysis. Guthertz, N. , van Der Kant, R. , Martinez, R. M. , Xu, Y. , Trinh, C. , Iorga, B. I. , Rousseau, F. , Schymkowitz, J. , Brockwell, D. J. and Radford, S. E. (2022) Proceedings of the National Academy of Sciences of the United States of America, 119, . doi:10.1073/pnas.2200468119
  23. Trigger factor both holds and folds its client proteins. Wu, Kevin , Minshull, Thomas C. , Radford, Sheena E. , Calabrese, Antonio N. and Bardwell, James C. A. (2022) Nature Communications, 13, . doi:10.1038/s41467-022-31767-6
  24. Dynamic interplay between the periplasmic chaperone SurA and the BAM complex in outer membrane protein folding. Schiffrin, Bob , Machin, Jonathan M. , Karamanos, Theodoros K. , Zhuravleva, Anastasia , Brockwell, David J. , Radford, Sheena E. and Calabrese, Antonio N. (2022) Communications Biology, 5, . doi:10.1038/s42003-022-03502-w
  25. High-throughput directed evolution: a golden era for protein science. McLure, Romany J. , Radford, Sheena E. and Brockwell, David J. (2022) Trends in Chemistry, 4, 378-391. doi:10.1016/j.trechm.2022.02.004
  26. Generating ensembles of dynamic misfolding proteins. Karamanos, Theodoros K. , Kalverda, Arnout P. and Radford, Sheena E. (2022) Frontiers in Neuroscience, 16, . doi:10.3389/fnins.2022.881534
  27. Roll out the barrel! Outer membrane tension resolves an unexpected folding intermediate. Horne, Jim E. and Radford, Sheena E. (2022) Cell, 185, 1107-1109. doi:10.1016/j.cell.2022.03.001
  28. Tuning the rate of aggregation of hiapp into amyloid using small-molecule modulators of assembly. Xu, Yong, Maya-Martinez, Roberto, Guthertz, Nicolas, Heath, George R., Manfield, Iain W., Breeze, Alex,er L., Sobott, Frank, Foster, Richard and Radford, Sheena E. (2022) Nature Communications, 13, . doi:10.1038/s41467-022-28660-7
  29. Global proteotoxicity caused by human beta(2) microglobulin variants impairs the unfolded protein response in C. elegans. Good, Sarah C. , Dewison, Katherine M. , Radford, Sheena E. and van Oosten-Hawle, Patricija (2021) international Journal of Molecular Sciences, 22, . doi:10.3390/ijms221910752
  30. Alphafold: a special issue and a special time for protein science. Serpell, Louise C. , Radford, Sheena E. and Otzen, Daniel E. (2021) Journal of Molecular Biology, 433, . doi:
  31. The role of membrane destabilisation and protein dynamics in bam catalysed omp folding. White, Paul , Haysom, Samuel F. , Iadanza, Matthew G. , Higgins, Anna J. , Machin, Jonathan M. , Whitehouse, James M. , Horne, Jim E. , Schiffrin, Bob , Carpenter-Platt, Charlotte , Calabrese, Antonio N. , Storek, Kelly M. , Rutherford, Steven T. , Brockwell, David J. , Ranson, Neil A. and Radford, Sheena E. (2021) Nature Communications, 12, . doi:10.1038/s41467-021-24432-x
  32. Finding the sweet spot for chaperone activity. Radford, Sheena E. and Karamanos, Theodoros K. (2021) Nature Chemistry, 13, 397-399. doi:10.1038/s41557-021-00691-5
  33. Brazilin removes toxic alpha-synuclein and seeding competent assemblies from parkinson brain by altering conformational equilibrium. Nahass, George R. , Sun, Yuanzi , Xu, Yong , Batchelor, Mark , Reilly, Madeleine , Benilova, Iryna , Kedia, Niraja , Spehar, Kevin , Sobott, Frank , Sessions, Richard B. , Caughey, Byron , Radford, Sheena E. , Jat, Parmjit S. , Collinge, John and Bieschke, Jan (2021) Journal of Molecular Biology, 433, . doi:10.1016/j.jmb.2021.166878
  34. De novo design of transmembrane beta barrels. Vorobieva, Anastassia A. , White, Paul , Liang, Binyong , Horne, Jim E. , Bera, Asim K. , Chow, Cameron M. , Gerben, Stacey , Marx, Sinduja , Kang, Alex , Stiving, Alyssa Q. , Harvey, Sophie R. , Marx, Dagan C. , Khan, G. Nasir , Fleming, Karen G. , Wysocki, Vicki H. , Brockwell, David J. , Tamm, Lukas K. , Radford, Sheena E. and Baker, David (2021) Science, 371, 801+. doi:10.1126/science.abc8182
  35. Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for Type II diabetes. Milardi, Danilo , Gazit, Ehud , Radford, Sheena E. , Xu, Yong , Gallardo, Rodrigo U. , Caflisch, Amedeo , Westermark, Gunilla T. , Westermark, Per , La Rosa, Carmelo and Ramamoorthy, Ayyalusamy (2021) Chemical Reviews, 121, 1845-1893. doi:10.1021/acs.chemrev.0c00981
  36. Investigation of D76N beta(2)-microglobulin using protein footprinting and structural mass spectrometry. Cornwell, Owen , Ault, James R. , Bond, Nicholas J. , Radford, Sheena E. and Ashcroft, Alison E. (2021) Journal of the American Society for Mass Spectrometry, 32, 1583-1592. doi:10.1021/jasms.0c00438
  37. Visualizing and trapping transient oligomers in amyloid assembly pathways. Cawood, Emma E. , Karamanos, Theodoros K. , Wilson, Andrew J. and Radford, Sheena E. (2021) Biophysical Chemistry, 268, . doi:10.1016/j.bpc.2020.106505
  38. Modulation of amyloidogenic protein self-assembly using tethered small molecules. Cawood, Emma E. , Guthertz, Nicolas , Ebo, Jessica S. , Karamanos, Theodoros K. , Radford, Sheena E. and Wilson, Andrew J. (2020) Journal of the American Chemical Society, 142, 20845-20854. doi:10.1021/jacs.0c10629
  39. Distortion of the bilayer and dynamics of the BAM complex in lipid nanodiscs. Iadanza, Matthew G. , Schiffrin, Bob , White, Paul , Watson, Matthew A. , Horne, Jim E. , Higgins, Anna J. , Calabrese, Antonio N. , Brockwell, David J. , Tuma, Roman , Kalli, Antreas C. , Radford, Sheena E. and Ranson, Neil A. (2020) Communications Biology, 3, . doi:10.1038/s42003-020-01419-w
  40. Looking beyond the core: the role of flanking regions in the aggregation of amyloidogenic peptides and proteins. Ulamec, Sabine M. , Brockwell, David J. and Radford, Sheena E. (2020) Frontiers in Neuroscience, 14, . doi:10.3389/fnins.2020.611285
  41. Modulation of beta-amyloid fibril formation in Alzheimer's disease by microglia and infection. Brown, Madeleine R. , Radford, Sheena E. and Hewitt, Eric W. (2020) Frontiers in Molecular Neuroscience, 13, . doi:10.3389/fnmol.2020.609073
  42. Structural insights into peptide self-assembly using photo-induced crosslinking experiments and discontinuous molecular dynamics. Bunce, Samuel J. , Wang, Yiming , Radford, Sheena E. , Wilson, Andrew J. and Hall, Carol K. (2020) Aiche Journal, , . doi:10.1002/aic.17101
  43. The uniqueness of flow in probing the aggregation behavior of clinically relevant antibodies. Willis, Leon F. , Kumar, Amit , Jain, Tushar , Caffrey, Isabelle , Xu, Yingda , Radford, Sheena E. , Kapur, Nikil , Vasquez, Maximiliano and Brockwell, David J. (2020) Engineering Reports, 27, 1094. doi:10.1002/eng2.12147
  44. Fibril structures of diabetes-related amylin variants reveal a basis for surface-templated assembly. Gallardo, Rodrigo , Iadanza, Matthew G. , Xu, Yong , Heath, George R. , Foster, Richard , Radford, Sheena E. and Ranson, Neil A. (2020) Nature Structural & Molecular Biology, 27, 1094. doi:10.1038/s41594-020-00525-x, Early Access Date = OCT 2020
  45. Potential human transmission of amyloid beta pathology: surveillance and risks. Lauwers, Elsa , Lalli, Giovanna , Br,ner, Sebastian , Collinge, John , Compernolle, Veerle , Duyckaerts, Charles , Edgren, Gustaf , Haik, Stephane , Hardy, John , Helmy, Adel , Ivinson, Adrian J. , Jaunmuktane, Zane , Jucker, Mathias , Knight, Richard , Lemmens, Robin , Lin, I-Chun , Love, Seth , Mead, Simon , Perry, V. Hugh , Pickett, James , Poppy, Guy , Radford, Sheena E. , Rousseau, Frederic , Routledge, Carol , Schiavo, Giampietro , Schymkowitz, Joost , Selkoe, Dennis J. , Smith, Colin , Thal, Dietmar R. , Theys, Tom , Tiberghien, Pierre , van den Burg, Peter , V,ekerckhove, Philippe , Walton, Clare , Zaaijer, Hans L. , Zetterberg, Henrik and De Strooper, Bart (2020) Lancet Neurology, 19, 872-878. doi:
  46. The role of the IT-state in D76N beta(2)-microglobulin amyloid assembly: a crucial intermediate or an innocuous bystander?. Smith, I, Hugh , Guthertz, Nicolas , Cawood, Emma E. , Maya-Martinez, Roberto , Breeze, Alex,er L. and Radford, Sheena E. (2020) Journal of Biological Chemistry, 295, 12474-12484. doi:10.1074/jbc.RA120.014901
  47. Spot the difference: function versus toxicity in amyloid fibrils. Ulamec, Sabine M. and Radford, Sheena E. (2020) Trends in Biochemical Sciences, 45, 635-636. doi:10.1016/j.tibs.2020.04.007
  48. Role of the lipid bilayer in outer membrane protein folding in gram-negative bacteria. Horne, Jim E. , Brockwell, David J. and Radford, Sheena E. (2020) Journal of Biological Chemistry, 295, 10340-10367. doi:10.1074/jbc.REV120.011473
  49. Macromolecular crowding enhances the detection of DNA and proteins by a solid-state nanopore. Chau, Chalmers C. , Radford, Sheena E. , Hewitt, Eric W. and Actis, Paolo (2020) Nano Letters, 20, 5553-5561. doi:10.1021/acs.nanolett.0c02246
  50. A potent sybody selectively inhibits α-synuclein amyloid formation by binding to the p1 region. Gialama, Dimitra , Vadukul, Devkee M. , Thrush, Rebecca J. , Radford, Sheena E. and Aprile, Francesco A. (2024) Journal of Medicinal Chemistry, 67, 9857-9868. doi:10.1021/acs.jmedchem.3c02408
  51. Cryoet of β-amyloid and tau within postmortem Alzheimer's disease brain. Gilbert, Madeleine A. G. , Fatima, Nayab , Jenkins, Joshua , O'Sullivan, Thomas J. , Schertel, Andreas , Halfon, Yehuda , Wilkinson, Martin , Morrema, Tjado H. J. , Geibel, Mirjam , Read, R,y J. , Ranson, Neil A. , Radford, Sheena E. , Hoozemans, Jeroen J. M. and Frank, Rene A. W. (2024) Nature, , . doi:10.1038/s41586-024-07680-x
  52. Single molecule delivery into living cells. Chau, Chalmers C. , Maffeo, Christopher M. , Aksimentiev, Aleksei , Radford, Sheena E. , Hewitt, Eric W. and Actis, Paolo (2024) Nature Communications, 15, . doi:10.1038/s41467-024-48608-3
  53. Pyxlinkviewer: a flexible tool for visualization of protein chemical crosslinking data within thepymolmolecular graphics system. Schiffrin, Bob , Radford, Sheena E. , Brockwell, David J. and Calabrese, Antonio N. (2020) Protein Science, 29, 1851-1857. doi:10.1002/pro.3902, Early Access Date = JUL 2020
  54. Structural insight into the formation of lipoprotein-beta-barrel complexes. Rodriguez-Alonso, Raquel , Letoquart, Juliette , Van Son Nguyen , Louis, Gwennaelle , Calabrese, Antonio N. , Iorga, Bogdan I. , Radford, Sheena E. , Cho, Seung-Hyun , Remaut, Han and Collet, Jean-Francois () Nature Chemical Biology, , . doi:10.1038/s41589-020-0575-0, Early Access Date = JUN 2020
  55. Inter-domain dynamics in the chaperone SurA and multi-site binding to its outer membrane protein clients. Calabrese, Antonio N. , Schiffrin, Bob , Watson, Matthew , Karamanos, Theodoros K. , Walko, Martin , Humes, Julia R. , Horne, Jim E. , White, Paul , Wilson, Andrew J. , Kalli, Antreas C. , Tuma, Roman , Ashcroft, Alison E. , Brockwell, David J. and Radford, Sheena E. (2020) Nature Communications, 11, . doi:10.1038/s41467-020-15702-1
  56. An in vivo platform to select and evolve aggregation-resistant proteins. Ebo, Jessica S. , Saunders, Janet C. , Devine, Paul W. A. , Gordon, Alice M. , Warwick, Amy S. , Schiffrin, Bob , Chin, Stacey E. , Engl,, Elizabeth , Button, James D. , Lloyd, Christopher , Bond, Nicholas J. , Ashcroft, Alison E. , Radford, Sheena E. , Lowe, David C. and Brockwell, David J. (2020) Nature Communications, 11, . doi:10.1038/s41467-020-15667-1
  57. A short motif in the N-terminal region of alpha-synuclein is critical for both aggregation and function. Doherty, Ciaran P. A. , Ulamec, Sabine M. , Maya-Martinez, Roberto , Good, Sarah C. , Makepeace, Jemma , Khan, G. Nasir , van Oosten-Hawle, Patricija , Radford, Sheena E. and Brockwell, David J. (2020) Nature Structural & Molecular Biology, 27, 249+. doi:10.1038/s41594-020-0384-x
  58. Amyloid structures: much more than just a cross-beta fold. Gallardo, Rodrigo , Ranson, Neil A. and Radford, Sheena E. (2020) Current Opinion in Structural Biology, 60, 7-16. doi:10.1016/j.sbi.2019.09.001
  59. Using protein engineering to understand and modulate aggregation. Ebo, Jessica S. , Guthertz, Nicolas , Radford, Sheena E. and Brockwell, David J. (2020) Current Opinion in Structural Biology, 60, 157-166. doi:10.1016/j.sbi.2020.01.005
  60. Collagen I weakly interacts with the beta-sheets of beta(2)-microglobulin and enhances conformational exchange to induce amyloid formation. Hoop, Cody L. , Zhu, Jie , Bhattacharya, Shibani , Tobita, Caitlyn A. , Radford, Sheena E. and Baum, Jean (2020) Journal of the American Chemical Society, 142, 1321-1331. doi:10.1021/jacs.9b10421
  61. Homage to Chris Dobson. Baum, Jean , Chiti, Fabrizio , De Simone, Alfonso , Knowles, Tuomas P. J. , Kumita, Janet R. , Radford, Sheena E. , Robinson, Carol V. , Salvatella, Xavier , Valelli, Karen , Vendruscolo, Michele , Pastore, Annalisa and Tartaglia, Gian Gaetano (2019) Frontiers in Molecular Biosciences, 6, . doi:10.3389/fmolb.2019.00137
  62. Long-range conformational changes in monoclonal antibodies revealed using FPOP-LS-MS/MS. Cornwell, Owen , Bond, Nicholas J. , Radford, Sheena E. and Ashcroft, Alison E. (2019) Analytical Chemistry, 91, 15163-15170. doi:10.1021/acs.analchem.9b03958
  63. Structural mapping of oligomeric intermediates in an amyloid assembly pathway. Karamanos, Theodoros K. , Jackson, Matthew P. , Calabrese, Antonio N. , Goodchild, Sophia C. , Cawood, Emma E. , Section, Gary S. Thompson , Kalverda, Arnout P. , Hewitt, Eric W. and Radford, Sheena E. (2019) Elife, 8, . doi:10.7554/eLife.46574
  64. Extracellular matrix components modulate different stages in (2)-microglobulin amyloid formation. Benseny-Cases, Nuria , Karamanos, Theodoros K. , Hoop, Cody L. , Baum, Jean and Radford, Sheena E. (2019) Journal of Biological Chemistry, 294, 9392-9401. doi:10.1074/jbc.RA119.008300
  65. Molecular insights into the surface-catalyzed secondary nucleation of amyloid-beta(40) (a beta(40)) by the peptide fragment a beta(16-22). Bunce, Samuel J. , Wang, Yiming , Stewart, Katie L. , Ashcroft, Alison E. , Radford, Sheena E. , Hall, Carol K. and Wilson, Andrew J. (2019) Science Advances, 5, . doi:10.1126/sciadv.aav8216
  66. Dual role of ribosome-binding domain of nac as a potent suppressor of protein aggregation and aging-related proteinopathies. Shen, Koning , Gamerdinger, Martin , Chan, Rebecca , Gense, Karina , Martin, Esther M. , Sachs, Nadine , Knight, Patrick D. , Schloemer, Renate , Calabrese, Antonio N. , Stewart, Katie L. , Leiendecker, Lukas , Baghel, Ankit , Radford, Sheena E. , Frydman, Judith and Deuerling, Elke (2019) Molecular Cell, 74, 729+. doi:10.1016/j.molcel.2019.03.012
  67. The role of SurA pplase domains in preventing aggregation of the outer-membrane proteins tOmpA and OmpT. Humes, Julia R. , Schiffrin, Bob , Calabrese, Antonio N. , Higgins, Anna J. , Westhead, David R. , Brockwell, David J. and Radford, Sheena E. (2019) Journal of Molecular Biology, 431, 1267-1283. doi:10.1016/j.jmb.2019.01.032
  68. Thermodynamic phase diagram of amyloid-beta (16-22) peptide. Wang, Yiming , Bunce, Samuel J. , Radford, Sheena E. , Wilson, Andrew J. , Auer, Stefan and Hall, Carol K. (2019) Proceedings of the National Academy of Sciences of the United States of America, 116, 2091-2096. doi:10.1073/pnas.1819592116
  69. Design and synthesis of cysteine-specific labels for photo-crosslinking studies. Walko, Martin , Hewitt, Eric , Radford, Sheena E. and Wilson, Andrew J. (2019) Rsc Advances, 9, 7610-7614. doi:10.1039/c8ra10436k
  70. Rapid mapping of protein interactions using tag-transfer photocrosslinkers. Horne, Jim E. , Walko, Martin , Calabrese, Antonio N. , Levenstein, Mark A. , Brockwell, David J. , Kapur, Nikil , Wilson, Andrew J. and Radford, Sheena E. (2018) Angewandte Chemie-international Edition, 57, 16688-16692. doi:10.1002/anie.201809149
  71. A new era for understanding amyloid structures and disease. Iadanza, Matthew G. , Jackson, Matthew P. , Hewitt, Eric W. , Ranson, Neil A. and Radford, Sheena E. (2018) Nature Reviews Molecular Cell Biology, 19, 755-773. doi:10.1038/s41580-018-0060-8
  72. Comparing hydrogen deuterium exchange and fast photochemical oxidation of proteins: a structural characterisation of wild-type and Delta N6 beta(2)-microglobulin. Cornwell, Owen , Radford, Sheena E. , Ashcroft, Alison E. and Ault, James R. (2018) Journal of the American Society for Mass Spectrometry, 29, 2413-2426. doi:10.1007/s13361-018-2067-y
  73. Orientation of a diagnostic ligand bound to macroscopically aligned amyloid-beta fibrils determined by solid-state NMR. Townsend, David , Hughes, Eleri , Stewart, Katie L. , Griffin, John M. , Radford, Sheena E. and Middleton, David A. (2018) Journal of Physical Chemistry Letters, 9, 6611-6615. doi:10.1021/acs.jpclett.8b02448
  74. The structure of a beta(2)-microglobulin fibril suggests a molecular basis for its amyloid polymorphism. Iadanza, Matthew G. , Silvers, Robert , Boardman, Joshua , Smith, Hugh I. , Karamanos, Theodoros K. , Debelouchina, Galia T. , Su, Yongchao , Griffin, Robert G. , Ranson, Neil A. and Radford, Sheena E. (2018) Nature Communications, 9, . doi:10.1038/s41467-018-06761-6
  75. Mass spectrometry-enabled structural biology of membrane proteins. Calabrese, Antonio N. and Radford, Sheena E. (2018) Methods, 147, 187-205. doi:10.1016/j.ymeth.2018.02.020
  76. Epigallocatechin-3-gallate remodels apolipoprotein a-i amyloid fibrils into soluble oligomers in the presence of heparin. Townsend, David , Hughes, Eleri , Akien, Geoffrey , Stewart, Katie L. , Radford, Sheena E. , Rochester, David and Middleton, David A. (2018) Journal of Biological Chemistry, 293, 12877-12893. doi:10.1074/jbc.RA118.002038
  77. A peptide-display protein scaffold to facilitate single molecule force studies of aggregation-prone peptides. Doherty, Ciaran P. A. , Young, Lydia M. , Karamanos, Theodoros K. , Smith, Hugh I. , Jackson, Matthew P. , Radford, Sheena E. and Brockwell, David J. (2018) Protein Science, 27, 1205-1217. doi:10.1002/pro.3386
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  166. Second order rate constants of donor-strand exchange reveal individual amino acid residues important in determining the subunit specificity of pilus biogenesis. Leney, Aneika C. , Phan, Gilles , Allen, William , Verger, Denis , Waksman, Gabriel , Radford, Sheena E. and Ashcroft, Alison E. (2011) Journal of the American Society for Mass Spectrometry, 22, 1214-1223. doi:10.1007/s13361-011-0146-4
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  171. The oligomeric state and arrangement of the active bacterial translocon. Deville, Karine , Gold, Vicki A. M. , Robson, Alice , Whitehouse, Sarah , Sessions, Richard B. , Baldwin, Stephen A. , Radford, Sheena E. and Collinson, Ian (2011) Journal of Biological Chemistry, 286, 4659-4669. doi:10.1074/jbc.M110.175638
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  173. Quantifying heterogeneity and conformational dynamics from single molecule fret of diffusing molecules: recurrence analysis of single particles (rasp). Hoffmann, Armin , Nettels, Daniel , Clark, Jennifer , Borgia, Aless,ro , Radford, Sheena E. , Clarke, Jane and Schuler, Benjamin (2011) Physical Chemistry Chemical Physics, 13, 1857-1871. doi:10.1039/c0cp01911a
  174. Perturbing the folding energy landscape of the bacterial immunity protein Im7 by site-specific N-linked glycosylation. Chen, Mark M. , Bartlett, Alice I. , Nerenberg, Paul S. , Friel, Claire T. , Hackenberger, Christian P. R. , Stultz, Collin M. , Radford, Sheena E. and Imperiali, Barbara (2010) Proceedings of the National Academy of Sciences of the United States of America, 107, 22528-22533. doi:10.1073/pnas.1015356107
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  177. Magic angle spinning NMR analysis of beta(2)-microglobulin amyloid fibrils in two distinct morphologies. Debelouchina, Galia T. , Platt, Geoffrey W. , Bayro, Marvin J. , Radford, Sheena E. and Griffin, Robert G. (2010) Journal of the American Chemical Society, 132, 10414-10423. doi:10.1021/ja102775u
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  186. Tuning the elastic modulus of hydrated collagen fibrils. Grant, Colin A. , Brockwell, David J. , Radford, Sheena E. and Thomson, Neil H. (2009) Biophysical Journal, 97, 2985-2992. doi:10.1016/j.bpj.2009.09.010
  187. Identification of a mechanical rheostat in the hydrophobic core of protein l. Sadler, David P. , Petrik, Eva , Taniguchi, Yukinori , Pullen, James R. , Kawakami, Masaru , Radford, Sheena E. and Brockwell, David J. (2009) Journal of Molecular Biology, 393, 237-248. doi:10.1016/j.jmb.2009.08.015
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  194. An expanding arsenal of experimental methods yields an explosion of insights into protein folding mechanisms. Bartlett, Alice I. and Radford, Sheena E. (2009) Nature Structural & Molecular Biology, 16, 582-588. doi:10.1038/nsmb.1592
  195. Globular tetramers of beta(2)-microglobulin assemble into elaborate amyloid fibrils. White, Helen E. , Hodgkinson, Julie L. , Jahn, Thomas R. , Cohen-Krausz, Sara , Gosal, Walraj S. , Mueller, Shirley , Orlova, Elena V. , Radford, Sheena E. and Saibil, Helen R. (2009) Journal of Molecular Biology, 389, 48-57. doi:10.1016/j.jmb.2009.03.066
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  201. Deciphering drift time measurements from travelling wave ion mobility spectrometry-mass spectrometry studies. Smith, David P. , Knapman, Tom W. , Campuzano, Iain , Malham, Richard W. , Berryman, Joshua T. , Radford, Sheena E. and Ashcroft, Atison E. (2009) European Journal of Mass Spectrometry, 15, 113-130. doi:10.1255/ejms.947
  202. Structural insights into the polymorphism of amyloid-like fibrils formed by region 20-29 of amylin revealed by solid-state NMR and X-ray fiber diffraction. Madine, Jillian , Jack, Edward , Stockley, Peter G. , Radford, Sheena E. , Serpell, Louise C. and Middleton, David A. (2008) Journal of the American Chemical Society, 130, 14990-15001. doi:10.1021/ja802483d
  203. Structural determinants of polymerization reactivity of the P pilus adaptor subunit PapF. Verger, Denis , Rose, Rebecca J. , Paci, Emanuele , Costakes, Greg , Daviter, Tina , Hultgren, Scott , Remaut, Han , Ashcroft, Alison E. , Radford, Sheena E. and Waksman, Gabriel (2008) Structure, 16, 1724-1731. doi:10.1016/j.str.2008.08.012
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  205. Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly. Xue, Wei-Feng , Homans, Steve W. and Radford, Sheena E. (2008) Proceedings of the National Academy of Sciences of the United States of America, 105, 8926-8931. doi:10.1073/pnas.0711664105
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  207. Effects of hydration on the mechanical response of individual collagen fibrils. Grant, Colin A. , Brockwell, David J. , Radford, Sheena E. and Thomson, Neil H. (2008) Applied Physics Letters, 92, . doi:10.1063/1.2937001
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  211. Trifluoromethyldiazirine: an effective photo-induced cross-linking probe for exploring amyloid formation. Smith, David P. , Anderson, Jon , Plante, Jeffrey , Ashcroft, Alison E. , Radford, Sheena E. , Wilson, Andrew J. and Parker, Martin J. (2008) Chemical Communications, , 5728-5730. doi:10.1039/b813504e
  212. InteRNAl friction of single polypeptide chains at high stretch. Khatri, Bhavin S. , Byrne, Katherine , Kawakami, Masaru , Brockwell, David J. , Smith, D. Alastair , Radford, Sheena E. and McLeish, Tom C. B. (2008) Faraday Discussions, 139, 35-51. doi:10.1039/b716418c
  213. Monitoring copopulated conformational states during protein folding events using electrospray ionization-ion mobility spectrometry-mass spectrometry. Smith, David P. , Giles, Kevin , Bateman, Robert H. , Radford, Sheena E. and Ashcroft, Alison E. (2007) Journal of the American Society for Mass Spectrometry, 18, 2180-2190. doi:10.1016/j.jasms.2007.09.017
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  224. Progressive glycosylation of albumin and its effect on the binding of homocysteine may be a key step in the pathogenesis of vascular damage in diabetes mellitus. Mathai, M. , Radford, S. E. , Holland, P. (2007) Medical Hypotheses, 69, 166-172. doi:10.1016/j.mehy.2006.10.050
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  229. Viscoelastic study of the mechanical unfolding of a protein by afm. Kawakami, Masaru , Byrne, Katherine , Brockwell, David J. , Radford, Sheena E. and Smith, D. Alastair (2006) Biophysical Journal, 91, L16-L18. doi:10.1529/biophysj.106.085019
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  232. GroEL: more than just a folding cage. Radford, Sheena E. (2006) Cell, 125, 831-833. doi:10.1016/j.cell.2006.05.021
  233. Detailed evaluation of the performance of microfluidic t mixers using fluorescence and ultraviolet resonance raman spectroscopy. Masca, Sergiu I. , Rodriguez-Mendieta, Inigo R. , Friel, Claire T. , Radford, Sheena E. and Smith, D. Alastair (2006) Review of Scientific instruments, 77, . doi:10.1063/1.2198800
  234. Amyloid formation under physiological conditions proceeds via a native-like folding intermediate. Jahn, TR , Parker, MJ , Homans, SW and Radford, SE (2006) Nature Structural & Molecular Biology, 13, 195-201. doi:10.1038/nsmb1058
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  236. A systematic study of the effect of physiological factors on beta 2-microglobulin amyloid formation at neutral ph. Myers, SL , Jones, S , Jahn, TR , Morten, IJ , Tennent, GA , Hewitt, EW and Radford, SE (2006) Biochemistry, 45, 2311-2321. doi:10.1021/bi052434i
  237. Determination of an ensemble of structures representing the intermediate state of the bacterial immunity protein Im7. Gsponer, J , Hopearuoho, H , Whittaker, SBM , Spence, GR , Moore, GR , Paci, E , Radford, SE and Vendruscolo, M (2006) Proceedings of the National Academy of Sciences of the United States of America, 103, 99-104. doi:10.1073/pnas.0508667102
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  242. Investigation into the role of lysosomes in dialysis related amyloidosis. Morten, IJ , Radford, SE and Hewitt, EW (2005) Immunology, 116, 63. doi:
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