Publications

  1. Finding the sweet spot for chaperone activity. Radford, Sheena E. and Karamanos, Theodoros K. (2021) Nature Chemistry, 13, 397-399. doi:10.1038/s41557-021-00691-5, Early Access Date = APR 2021
  2. Brazilin removes toxic alpha-synuclein and seeding competent assemblies from parkinson brain by altering conformational equilibrium. Nahass, George R. , Sun, Yuanzi , Xu, Yong , Batchelor, Mark , Reilly, Madeleine , Benilova, Iryna , Kedia, Niraja , Spehar, Kevin , Sobott, Frank , Sessions, Richard B. , Caughey, Byron , Radford, Sheena E. , Jat, Parmjit S. , Collinge, John and Bieschke, Jan (2021) Journal of Molecular Biology, 433, . doi:10.1016/j.jmb.2021.166878
  3. De novo design of transmembrane beta barrels. Vorobieva, Anastassia A. , White, Paul , Liang, Binyong , Horne, Jim E. , Bera, Asim K. , Chow, Cameron M. , Gerben, Stacey , Marx, Sinduja , Kang, Alex , Stiving, Alyssa Q. , Harvey, Sophie R. , Marx, Dagan C. , Khan, G. Nasir , Fleming, Karen G. , Wysocki, Vicki H. , Brockwell, David J. , Tamm, Lukas K. , Radford, Sheena E. and Baker, David (2021) Science, 371, 801+. doi:10.1126/science.abc8182
  4. Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for Type II diabetes. Milardi, Danilo , Gazit, Ehud , Radford, Sheena E. , Xu, Yong , Gallardo, Rodrigo U. , Caflisch, Amedeo , Westermark, Gunilla T. , Westermark, Per , La Rosa, Carmelo and Ramamoorthy, Ayyalusamy (2021) Chemical Reviews, 121, 1845-1893. doi:10.1021/acs.chemrev.0c00981
  5. Investigation of D76N β2-microglobulin using protein footprinting and structural mass spectrometry. Cornwell, Owen , Ault, James R , Bond, Nicholas J , Radford, Sheena E and Ashcroft, Alison E (2021) Journal of the American Society for Mass Spectrometry, , . doi:
  6. Visualizing and trapping transient oligomers in amyloid assembly pathways. Cawood, Emma E. , Karamanos, Theodoros K. , Wilson, Andrew J. and Radford, Sheena E. (2021) Biophysical Chemistry, 268, . doi:10.1016/j.bpc.2020.106505
  7. Modulation of amyloidogenic protein self-assembly using tethered small molecules. Cawood, Emma E. , Guthertz, Nicolas , Ebo, Jessica S. , Karamanos, Theodoros K. , Radford, Sheena E. and Wilson, Andrew J. (2020) Journal of the American Chemical Society, 142, 20845-20854. doi:10.1021/jacs.0c10629
  8. Distortion of the bilayer and dynamics of the BAM complex in lipid nanodiscs. Iadanza, Matthew G. , Schiffrin, Bob , White, Paul , Watson, Matthew A. , Horne, Jim E. , Higgins, Anna J. , Calabrese, Antonio N. , Brockwell, David J. , Tuma, Roman , Kalli, Antreas C. , Radford, Sheena E. and Ranson, Neil A. (2020) Communications Biology, 3, . doi:10.1038/s42003-020-01419-w
  9. Looking beyond the core: the role of flanking regions in the aggregation of amyloidogenic peptides and proteins. Ulamec, Sabine M. , Brockwell, David J. and Radford, Sheena E. (2020) Frontiers in Neuroscience, 14, . doi:10.3389/fnins.2020.611285
  10. Modulation of beta-amyloid fibril formation in Alzheimer's disease by microglia and infection. Brown, Madeleine R. , Radford, Sheena E. and Hewitt, Eric W. (2020) Frontiers in Molecular Neuroscience, 13, . doi:10.3389/fnmol.2020.609073
  11. Structural insights into peptide self-assembly using photo-induced crosslinking experiments and discontinuous molecular dynamics. Bunce, Samuel J. , Wang, Yiming , Radford, Sheena E. , Wilson, Andrew J. and Hall, Carol K. (2020) Aiche Journal, , . doi:10.1002/aic.17101
  12. The uniqueness of flow in probing the aggregation behavior of clinically relevant antibodies. Willis, Leon F. , Kumar, Amit , Jain, Tushar , Caffrey, Isabelle , Xu, Yingda , Radford, Sheena E. , Kapur, Nikil , Vasquez, Maximiliano and Brockwell, David J. (2020) Engineering Reports, 27, 1094. doi:10.1002/eng2.12147
  13. Fibril structures of diabetes-related amylin variants reveal a basis for surface-templated assembly. Gallardo, Rodrigo , Iadanza, Matthew G. , Xu, Yong , Heath, George R. , Foster, Richard , Radford, Sheena E. and Ranson, Neil A. (2020) Nature Structural & Molecular Biology, 27, 1094. doi:10.1038/s41594-020-00525-x, Early Access Date = OCT 2020
  14. Potential human transmission of amyloid beta pathology: surveillance and risks. Lauwers, Elsa , Lalli, Giovanna , Br,ner, Sebastian , Collinge, John , Compernolle, Veerle , Duyckaerts, Charles , Edgren, Gustaf , Haik, Stephane , Hardy, John , Helmy, Adel , Ivinson, Adrian J. , Jaunmuktane, Zane , Jucker, Mathias , Knight, Richard , Lemmens, Robin , Lin, I-Chun , Love, Seth , Mead, Simon , Perry, V. Hugh , Pickett, James , Poppy, Guy , Radford, Sheena E. , Rousseau, Frederic , Routledge, Carol , Schiavo, Giampietro , Schymkowitz, Joost , Selkoe, Dennis J. , Smith, Colin , Thal, Dietmar R. , Theys, Tom , Tiberghien, Pierre , van den Burg, Peter , V,ekerckhove, Philippe , Walton, Clare , Zaaijer, Hans L. , Zetterberg, Henrik and De Strooper, Bart (2020) Lancet Neurology, 19, 872-878. doi:
  15. The role of the IT-state in D76N beta(2)-microglobulin amyloid assembly: a crucial intermediate or an innocuous bystander?. Smith, I, Hugh , Guthertz, Nicolas , Cawood, Emma E. , Maya-Martinez, Roberto , Breeze, Alex,er L. and Radford, Sheena E. (2020) Journal of Biological Chemistry, 295, 12474-12484. doi:10.1074/jbc.RA120.014901
  16. Spot the difference: function versus toxicity in amyloid fibrils. Ulamec, Sabine M. and Radford, Sheena E. (2020) Trends in Biochemical Sciences, 45, 635-636. doi:10.1016/j.tibs.2020.04.007
  17. Role of the lipid bilayer in outer membrane protein folding in gram-negative bacteria. Horne, Jim E. , Brockwell, David J. and Radford, Sheena E. (2020) Journal of Biological Chemistry, 295, 10340-10367. doi:10.1074/jbc.REV120.011473
  18. Macromolecular crowding enhances the detection of DNA and proteins by a solid-state nanopore. Chau, Chalmers C. , Radford, Sheena E. , Hewitt, Eric W. and Actis, Paolo (2020) Nano Letters, 20, 5553-5561. doi:10.1021/acs.nanolett.0c02246
  19. Pyxlinkviewer: a flexible tool for visualization of protein chemical crosslinking data within thepymolmolecular graphics system. Schiffrin, Bob , Radford, Sheena E. , Brockwell, David J. and Calabrese, Antonio N. (2020) Protein Science, 29, 1851-1857. doi:10.1002/pro.3902, Early Access Date = JUL 2020
  20. Structural insight into the formation of lipoprotein-beta-barrel complexes. Rodriguez-Alonso, Raquel , Letoquart, Juliette , Van Son Nguyen , Louis, Gwennaelle , Calabrese, Antonio N. , Iorga, Bogdan I. , Radford, Sheena E. , Cho, Seung-Hyun , Remaut, Han and Collet, Jean-Francois () Nature Chemical Biology, , . doi:10.1038/s41589-020-0575-0, Early Access Date = JUN 2020
  21. Inter-domain dynamics in the chaperone SurA and multi-site binding to its outer membrane protein clients. Calabrese, Antonio N. , Schiffrin, Bob , Watson, Matthew , Karamanos, Theodoros K. , Walko, Martin , Humes, Julia R. , Horne, Jim E. , White, Paul , Wilson, Andrew J. , Kalli, Antreas C. , Tuma, Roman , Ashcroft, Alison E. , Brockwell, David J. and Radford, Sheena E. (2020) Nature Communications, 11, . doi:10.1038/s41467-020-15702-1
  22. An in vivo platform to select and evolve aggregation-resistant proteins. Ebo, Jessica S. , Saunders, Janet C. , Devine, Paul W. A. , Gordon, Alice M. , Warwick, Amy S. , Schiffrin, Bob , Chin, Stacey E. , Engl,, Elizabeth , Button, James D. , Lloyd, Christopher , Bond, Nicholas J. , Ashcroft, Alison E. , Radford, Sheena E. , Lowe, David C. and Brockwell, David J. (2020) Nature Communications, 11, . doi:10.1038/s41467-020-15667-1
  23. A short motif in the N-terminal region of alpha-synuclein is critical for both aggregation and function. Doherty, Ciaran P. A. , Ulamec, Sabine M. , Maya-Martinez, Roberto , Good, Sarah C. , Makepeace, Jemma , Khan, G. Nasir , van Oosten-Hawle, Patricija , Radford, Sheena E. and Brockwell, David J. (2020) Nature Structural & Molecular Biology, 27, 249+. doi:10.1038/s41594-020-0384-x
  24. Amyloid structures: much more than just a cross-beta fold. Gallardo, Rodrigo , Ranson, Neil A. and Radford, Sheena E. (2020) Current Opinion in Structural Biology, 60, 7-16. doi:10.1016/j.sbi.2019.09.001
  25. Using protein engineering to understand and modulate aggregation. Ebo, Jessica S. , Guthertz, Nicolas , Radford, Sheena E. and Brockwell, David J. (2020) Current Opinion in Structural Biology, 60, 157-166. doi:10.1016/j.sbi.2020.01.005
  26. Collagen I weakly interacts with the beta-sheets of beta(2)-microglobulin and enhances conformational exchange to induce amyloid formation. Hoop, Cody L. , Zhu, Jie , Bhattacharya, Shibani , Tobita, Caitlyn A. , Radford, Sheena E. and Baum, Jean (2020) Journal of the American Chemical Society, 142, 1321-1331. doi:10.1021/jacs.9b10421
  27. Homage to Chris Dobson. Baum, Jean , Chiti, Fabrizio , De Simone, Alfonso , Knowles, Tuomas P. J. , Kumita, Janet R. , Radford, Sheena E. , Robinson, Carol V. , Salvatella, Xavier , Valelli, Karen , Vendruscolo, Michele , Pastore, Annalisa and Tartaglia, Gian Gaetano (2019) Frontiers in Molecular Biosciences, 6, . doi:10.3389/fmolb.2019.00137
  28. Long-range conformational changes in monoclonal antibodies revealed using FPOP-LS-MS/MS. Cornwell, Owen , Bond, Nicholas J. , Radford, Sheena E. and Ashcroft, Alison E. (2019) Analytical Chemistry, 91, 15163-15170. doi:10.1021/acs.analchem.9b03958
  29. Structural mapping of oligomeric intermediates in an amyloid assembly pathway. Karamanos, Theodoros K. , Jackson, Matthew P. , Calabrese, Antonio N. , Goodchild, Sophia C. , Cawood, Emma E. , Section, Gary S. Thompson , Kalverda, Arnout P. , Hewitt, Eric W. and Radford, Sheena E. (2019) Elife, 8, . doi:10.7554/eLife.46574
  30. Extracellular matrix components modulate different stages in (2)-microglobulin amyloid formation. Benseny-Cases, Nuria , Karamanos, Theodoros K. , Hoop, Cody L. , Baum, Jean and Radford, Sheena E. (2019) Journal of Biological Chemistry, 294, 9392-9401. doi:10.1074/jbc.RA119.008300
  31. Molecular insights into the surface-catalyzed secondary nucleation of amyloid-beta(40) (a beta(40)) by the peptide fragment a beta(16-22). Bunce, Samuel J. , Wang, Yiming , Stewart, Katie L. , Ashcroft, Alison E. , Radford, Sheena E. , Hall, Carol K. and Wilson, Andrew J. (2019) Science Advances, 5, . doi:10.1126/sciadv.aav8216
  32. Dual role of ribosome-binding domain of nac as a potent suppressor of protein aggregation and aging-related proteinopathies. Shen, Koning , Gamerdinger, Martin , Chan, Rebecca , Gense, Karina , Martin, Esther M. , Sachs, Nadine , Knight, Patrick D. , Schloemer, Renate , Calabrese, Antonio N. , Stewart, Katie L. , Leiendecker, Lukas , Baghel, Ankit , Radford, Sheena E. , Frydman, Judith and Deuerling, Elke (2019) Molecular Cell, 74, 729+. doi:10.1016/j.molcel.2019.03.012
  33. The role of SurA pplase domains in preventing aggregation of the outer-membrane proteins tOmpA and OmpT. Humes, Julia R. , Schiffrin, Bob , Calabrese, Antonio N. , Higgins, Anna J. , Westhead, David R. , Brockwell, David J. and Radford, Sheena E. (2019) Journal of Molecular Biology, 431, 1267-1283. doi:10.1016/j.jmb.2019.01.032
  34. Thermodynamic phase diagram of amyloid-beta (16-22) peptide. Wang, Yiming , Bunce, Samuel J. , Radford, Sheena E. , Wilson, Andrew J. , Auer, Stefan and Hall, Carol K. (2019) Proceedings of the National Academy of Sciences of the United States of America, 116, 2091-2096. doi:10.1073/pnas.1819592116
  35. Design and synthesis of cysteine-specific labels for photo-crosslinking studies. Walko, Martin , Hewitt, Eric , Radford, Sheena E. and Wilson, Andrew J. (2019) Rsc Advances, 9, 7610-7614. doi:10.1039/c8ra10436k
  36. Rapid mapping of protein interactions using tag-transfer photocrosslinkers. Horne, Jim E. , Walko, Martin , Calabrese, Antonio N. , Levenstein, Mark A. , Brockwell, David J. , Kapur, Nikil , Wilson, Andrew J. and Radford, Sheena E. (2018) Angewandte Chemie-international Edition, 57, 16688-16692. doi:10.1002/anie.201809149
  37. A new era for understanding amyloid structures and disease. Iadanza, Matthew G. , Jackson, Matthew P. , Hewitt, Eric W. , Ranson, Neil A. and Radford, Sheena E. (2018) Nature Reviews Molecular Cell Biology, 19, 755-773. doi:10.1038/s41580-018-0060-8
  38. Comparing hydrogen deuterium exchange and fast photochemical oxidation of proteins: a structural characterisation of wild-type and Delta N6 beta(2)-microglobulin. Cornwell, Owen , Radford, Sheena E. , Ashcroft, Alison E. and Ault, James R. (2018) Journal of the American Society for Mass Spectrometry, 29, 2413-2426. doi:10.1007/s13361-018-2067-y
  39. Orientation of a diagnostic ligand bound to macroscopically aligned amyloid-beta fibrils determined by solid-state NMR. Townsend, David , Hughes, Eleri , Stewart, Katie L. , Griffin, John M. , Radford, Sheena E. and Middleton, David A. (2018) Journal of Physical Chemistry Letters, 9, 6611-6615. doi:10.1021/acs.jpclett.8b02448
  40. The structure of a beta(2)-microglobulin fibril suggests a molecular basis for its amyloid polymorphism. Iadanza, Matthew G. , Silvers, Robert , Boardman, Joshua , Smith, Hugh I. , Karamanos, Theodoros K. , Debelouchina, Galia T. , Su, Yongchao , Griffin, Robert G. , Ranson, Neil A. and Radford, Sheena E. (2018) Nature Communications, 9, . doi:10.1038/s41467-018-06761-6
  41. Mass spectrometry-enabled structural biology of membrane proteins. Calabrese, Antonio N. and Radford, Sheena E. (2018) Methods, 147, 187-205. doi:10.1016/j.ymeth.2018.02.020
  42. Epigallocatechin-3-gallate remodels apolipoprotein a-i amyloid fibrils into soluble oligomers in the presence of heparin. Townsend, David , Hughes, Eleri , Akien, Geoffrey , Stewart, Katie L. , Radford, Sheena E. , Rochester, David and Middleton, David A. (2018) Journal of Biological Chemistry, 293, 12877-12893. doi:10.1074/jbc.RA118.002038
  43. A peptide-display protein scaffold to facilitate single molecule force studies of aggregation-prone peptides. Doherty, Ciaran P. A. , Young, Lydia M. , Karamanos, Theodoros K. , Smith, Hugh I. , Jackson, Matthew P. , Radford, Sheena E. and Brockwell, David J. (2018) Protein Science, 27, 1205-1217. doi:10.1002/pro.3386
  44. The role of beta-barrels 1 and 2 in the enzymatic activity of factor xiii a-subunit. Hethershaw, E. L. , Adamson, P. J. , Smith, K. A. , Goldsberry, W. N. , Pease, R. J. , Radford, S. E. , Grant, P. J. , Ariens, R. A. S. , Maurer, M. C. and Philippou, H. (2018) Journal of Thrombosis and Haemostasis, 16, 1391-1401. doi:10.1111/jth.14128
  45. Dynamic action of the sec machinery during initiation, protein translocation and termination. Fessl, Tomas , Watkins, Daniel , Oatley, Peter , Allen, William John , Corey, Robin Adam , Horne, Jim , Baldwin, Steve A. , Radford, Sheena E. , Collinson, Ian and Tuma, Roman (2018) Elife, 7, . doi:10.7554/eLife.35112
  46. Conformational flexibility within the nascent polypeptide-associated complex enables its interactions with structurally diverse client proteins. Martin, Esther M. , Jackson, Matthew P. , Gamerdinger, Martin , Gense, Karina , Karamonos, Theodoros K. , Humes, Julia R. , Deuerling, Elke , Ashcroft, Alison E. and Radford, Sheena E. (2018) Journal of Biological Chemistry, 293, 8554-8568. doi:10.1074/jbc.RA117.001568
  47. Using extensional flow to reveal diverse aggregation landscapes for three IgG1 molecules. Willis, Leon F. , Kumar, Amit , Dobson, John , Bond, Nicholas J. , Lowe, David , Turner, Richard , Radford, Sheena E. , Kapur, Nikil and Brockwell, David J. (2018) Biotechnology and Bioengineering, 115, 1216-1225. doi:10.1002/bit.26543
  48. Identification of a novel site of interaction between ataxin-3 and the amyloid aggregation inhibitor polyglutamine binding peptide 1. Knight, Patrick D. , Karamanos, Theodoros K. , Radford, Sheena E. and Ashcroft, Alison E. (2018) European Journal of Mass Spectrometry, 24, 129-140. doi:10.1177/1469066717729298
  49. Outer membrane protein folding from an energy landscape perspective. Schiffrin, Bob , Brockwell, David J. and Radford, Sheena E. (2017) Bmc Biology, 15, . doi:10.1186/s12915-017-0464-5
  50. Effects of periplasmic chaperones and membrane thickness on bama-catalyzed outer-membrane protein folding. Schiffrin, Bob , Calabrese, Antonio N. , Higgins, Anna J. , Humes, Julia R. , Ashcroft, Alison E. , Kalli, Antreas C. , Brockwell, David J. and Radford, Sheena E. (2017) Journal of Molecular Biology, 429, 3776-3792. doi:10.1016/j.jmb.2017.09.008
  51. Topological dissection of the membrane transport protein mhp1 derived from cysteine accessibility and mass spectrometry. Calabrese, Antonio N. , Jackson, Scott M. , Jones, Lynsey N. , Beckstein, Oliver , Heinkel, Florian , Gsponer, Joerg , Sharples, David , Sans, Marta , Kokkinidou, Maria , Pearson, Arwen R. , Radford, Sheena E. , Ashcroft, Alison E. and Henderson, Peter J. F. (2017) Analytical Chemistry, 89, 8844-8852. doi:10.1021/acs.analchem.7b01310
  52. Investigating the structural compaction of biomolecules upon transition to the gas-phase using esi-twims-ms. Devine, Paul W. A. , Fisher, Henry C. , Calabrese, Antonio N. , Whelan, Fiona , Higazi, Daniel R. , Potts, Jennifer R. , Lowe, David C. , Radford, Sheena E. and Ashcroft, Alison E. (2017) Journal of the American Society for Mass Spectrometry, 28, 1855-1862. doi:10.1007/s13361-017-1689-9
  53. Molecular origins of the compatibility between glycosaminoglycans and a beta 40 amyloid fibrils. Stewart, Katie L. , Hughes, Eleri , Yates, Edwin A. , Middleton, David A. and Radford, Sheena E. (2017) Journal of Molecular Biology, 429, 2449-2462. doi:10.1016/j.jmb.2017.07.003
  54. Small molecule probes of protein aggregation. Young, Lydia M. , Ashcroft, Alison E. and Radford, Sheena E. (2017) Current Opinion in Chemical Biology, 39, 90-99. doi:10.1016/j.cbpa.2017.06.008
  55. Lateral opening in the intact beta-barrel assembly machinery captured by cryo-EM. Higgins, A. J. , Iadanza, M. G. , Schiffrin, B. , Calabrese, A. N. , Humes, J. R. , Brockwell, D. J. , Ashcroft, A. E. , Ranson, N. A. and Radford, S. E. (2017) European Biophysics Journal With Biophysics Letters, 46, S346. doi:
  56. Complementary cross-linking and fluorescence studies of outer membrane protein biogenesis in vitro. Horne, J. E. , Radford, S. E. and Brockwell, D. J. (2017) European Biophysics Journal With Biophysics Letters, 46, S346. doi:
  57. Identifying the contributions of the different domains within SurA on outer member protein folding. Humes, J. R. , Higgins, A. J. , Brockwell, D. J. and Radford, S. E. (2017) European Biophysics Journal With Biophysics Letters, 46, S346. doi:
  58. The challenges and opportunities of understanding protein folding and misfolding in health and disease. Radford, S. E. (2017) European Biophysics Journal With Biophysics Letters, 46, S44. doi:
  59. Understanding co-polymerization in amyloid formation by direct observation of mixed oligomers. Young, Lydia M. , Tu, Ling-Hsien , Raleigh, Daniel P. , Ashcroft, Alison E. and Radford, Sheena E. (2017) Chemical Science, 8, 5030-5040. doi:10.1039/c7sc00620a
  60. Inducing protein aggregation by extensional flow. Dobson, John , Kumar, Amit , Willis, Leon F. , Tuma, Roman , Higazi, Daniel R. , Turner, Richard , Lowe, David C. , Ashcroft, Alison E. , Radford, Sheena E. , Kapur, Nikil and Brockwell, David J. (2017) Proceedings of the National Academy of Sciences of the United States of America, 114, 4673-4678. doi:10.1073/pnas.1702724114
  61. Fretting about outer membrane protein biogenesis. How exactly do they fold?. Horne, Jim E. , Brockwell, David J. and Radford, Sheena E. (2017) Biophysical Journal, 112, 205A. doi:10.1016/j.bpj.2016.11.1131
  62. FPOP-LC-MS-MS suggests differences in interaction sites of amphipols and detergents with outer membrane proteins. Watkinson, Thomas G. , Calabrese, Antonio N. , Ault, James R. , Radford, Sheena E. and Ashcroft, Alison E. (2017) Journal of the American Society for Mass Spectrometry, 28, 50-55. doi:10.1007/s13361-016-1421-1
  63. Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo. Dobson, Claire L. , Devine, Paul W. A. , Phillips, Jonathan J. , Higazi, Daniel R. , Lloyd, Christopher , Popovic, Bojana , Arnold, Joanne , Buchanan, Andrew , Lewis, Arthur , Goodman, Joanne , van der Walle, Christopher F. , Thornton, Peter , Vinall, Lisa , Lowne, David , Aagaard, Anna , Olsson, Lise-Lotte , Wollberg, Anna Ridderstad , Welsh, Fraser , Karamanos, Theodoros K. , Pashley, Clare L. , Iadanza, Matthew G. , Ranson, Neil A. , Ashcroft, Alison E. , Kippen, Alistair D. , Vaughan, Tristan J. , Radford, Sheena E. and Lowe, David C. (2016) Scientific Reports, 6, . doi:10.1038/srep38644
  64. Lateral opening in the intact beta-barrel assembly machinery captured by cryo-EM. Iadanza, Matthew G. , Higgins, Anna J. , Schiffrin, Bob , Calabrese, Antonio N. , Brockwell, David J. , Ashcroft, Alison E. , Radford, Sheena E. and Ranson, Neil A. (2016) Nature Communications, 7, . doi:10.1038/ncomms12865
  65. Skp is a multivalent chaperone of outer-membrane proteins. Schiffrin, Bob , Calabrese, Antonio N. , Devine, Paul W. A. , Harris, Sarah A. , Ashcroft, Alison E. , Brockwell, David J. and Radford, Sheena E. (2016) Nature Structural & Molecular Biology, 23, 786-793. doi:10.1038/nsmb.3266
  66. Atomic details of the interactions of glycosaminoglycans with amyloid-beta fibrils. Stewart, Katie L. , Hughes, Eleri , Yates, Edwin A. , Akien, Geoffrey R. , Huang, Teng-Yi , Lima, Marcelo A. , Rudd, Timothy R. , Guerrini, Marco , Hung, Shang-Cheng , Radford, Sheena E. and Middleton, David A. (2016) Journal of the American Chemical Society, 138, 8328-8331. doi:10.1021/jacs.6b02816
  67. A growing toolbox of techniques for studying beta-barrel outer membrane protein folding and biogenesis. Horne, Jim E. and Radford, Sheena E. (2016) Biochemical Society Transactions, 44, 802-809. doi:10.1042/BST20160020
  68. A population shift between sparsely populated folding intermediates determines amyloidogenicity. Karamanos, Theodoros K. , Pashley, Clare L. , Kalverda, Arnout P. , Thompson, Gary S. , Mayzel, Maxim , Orekhov, Vladislav Y. and Radford, Sheena E. (2016) Journal of the American Chemical Society, 138, 6271-6280. doi:10.1021/jacs.6b02464
  69. Two-way communication between secy and seca suggests a brownian ratchet mechanism for protein translocation. Allen, William John , Corey, Robin Adam , Oatley, Peter , Sessions, Richard Barry , Baldwin, Steve A. , Radford, Sheena E. , Tuma, Roman and Collinson, Ian (2016) Elife, 5, . doi:10.7554/eLife.15598
  70. Esi-ims-ms: a method for rapid analysis of protein aggregation and its inhibition by small molecules. Young, Lydia M. , Saunders, Janet C. , Mahood, Rachel A. , Revill, Charlotte H. , Foster, Richard J. , Ashcroft, Alison E. and Radford, Sheena E. (2016) Methods, 95, 62-69. doi:10.1016/j.ymeth.2015.05.017
  71. Comparison of the aggregation of homologous beta(2)-microglobulin variants reveals protein solubility as a key determinant of amyloid formation. Pashley, Clare L. , Hewitt, Eric W. and Radford, Sheena E. (2016) Journal of Molecular Biology, 428, 631-643. doi:10.1016/j.jmb.2016.01.009
  72. Mpul-multi: software for calculation of amyloid fibril mass per unit length from tb-tem images. Iadanza, Matthew G. , Jackson, Matthew P. , Radford, Sheena E. and Ranson, Neil A. (2016) Scientific Reports, 6, . doi:10.1038/srep21078
  73. An in vivo platform for identifying inhibitors of protein aggregation. Saunders, Janet C. , Young, Lydia M. , Mahood, Rachel A. , Jackson, Matthew P. , Revill, Charlotte H. , Foster, Richard J. , Smith, D. Alastair , Ashcroft, Alison E. , Brockwell, David J. and Radford, Sheena E. (2016) Nature Chemical Biology, 12, 94+. doi:10.1038/NCHEMBIO.1988
  74. Substrate protein folds while it is bound to the ATP-independent chaperone spy. Stull, Frederick , Koldewey, Philipp , Humes, Julia R. , Radford, Sheena E. and Bardwell, James C. A. (2016) Nature Structural & Molecular Biology, 23, 53-58. doi:10.1038/nsmb.3133
  75. Amyloid fibres: inert end-stage aggregates or key players in disease?. Tipping, Kevin W. , van Oosten-Hawle, Patricija , Hewitt, Eric W. and Radford, Sheena E. (2015) Trends in Biochemical Sciences, 40, 719-727. doi:10.1016/j.tibs.2015.10.002
  76. Systematic analysis of the use of amphipathic polymers for studies of outer membrane proteins using mass spectrometry. Watkinson, Thomas G. , Calabrese, Antonio N. , Giusti, Fabrice , Zoonens, Manuela , Radford, Sheena E. and Ashcroft, Alison E. (2015) international Journal of Mass Spectrometry, 391, 54-61. doi:10.1016/j.ijms.2015.06.017
  77. Mass spectrometric methods to analyze the structural organization of macromolecular complexes. Rajabi, Khadijeh , Ashcroft, Alison E. and Radford, Sheena E. (2015) Methods, 89, 13-21. doi:10.1016/j.ymeth.2015.03.004
  78. Using hydroxyl radical footprinting to explore the free energy landscape of protein folding. Calabrese, Antonio N. , Ault, James R. , Radford, Sheena E. and Ashcroft, Alison E. (2015) Methods, 89, 38-44. doi:10.1016/j.ymeth.2015.02.018
  79. Mechanisms of amyloid formation revealed by solution NMR. Karamanos, Theodoros K. , Kalverda, Arnout P. , Thompson, Gary S. and Radford, Sheena E. (2015) Progress in Nuclear Magnetic Resonance Spectroscopy, 88-89, 86-104. doi:10.1016/j.pnmrs.2015.05.002
  80. A comparison of the folding characteristics of free and ribosome-tethered polypeptide chains using limited proteolysis and mass spectrometry. Rajabi, Khadijeh , Reuther, Julia , Deuerling, Elke , Radford, Sheena E. and Ashcroft, Alison E. (2015) Protein Science, 24, 1282-1291. doi:10.1002/pro.2702
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“ Proteins hold the key to the whole subject of the molecular basis of biological reactions. ”