Publications

  1. Single residue modulators of amyloid formation in the N-terminal p1-region of alpha-synuclein. {Ulamec, Sabine M. , Maya-Martinez, Roberto , Byrd, Emily J. , Dewison, Katherine M. , Xu, Yong , Willis, Leon F. , Sobott, Frank , Heath, George R. , Hawle, Patricija van Oosten , Buchman, Vladimir L. , Radford, Sheena E. and Brockwell, David J.} (2022) Nature Communications, 13, . doi:10.1038/s41467-022-32687-1
  2. Sequence grammar underlying the unfolding and phase separation of globular proteins. Ruff, Kiersten M. , Choi, Yoon Hee , Cox, Dezerae , Ormsby, Angelique R. , Myung, Yoochan , Ascher, David B. , Radford, Sheena E. , V. Pappu, Rohit and Hatters, Danny M. (2022) Molecular Cell, 82, 3193+. doi:10.1016/j.molcel.2022.06.024
  3. The effect of mutation on an aggregation-prone protein: an in vivo, in vitro, and in silico analysis. Guthertz, N. , van Der Kant, R. , Martinez, R. M. , Xu, Y. , Trinh, C. , Iorga, B. I. , Rousseau, F. , Schymkowitz, J. , Brockwell, D. J. and Radford, S. E. (2022) Proceedings of the National Academy of Sciences of the United States of America, 119, . doi:10.1073/pnas.2200468119
  4. Trigger factor both holds and folds its client proteins. Wu, Kevin , Minshull, Thomas C. , Radford, Sheena E. , Calabrese, Antonio N. and Bardwell, James C. A. (2022) Nature Communications, 13, . doi:10.1038/s41467-022-31767-6
  5. Dynamic interplay between the periplasmic chaperone SurA and the BAM complex in outer membrane protein folding. Schiffrin, Bob , Machin, Jonathan M. , Karamanos, Theodoros K. , Zhuravleva, Anastasia , Brockwell, David J. , Radford, Sheena E. and Calabrese, Antonio N. (2022) Communications Biology, 5, . doi:10.1038/s42003-022-03502-w
  6. High-throughput directed evolution: a golden era for protein science. McLure, Romany J. , Radford, Sheena E. and Brockwell, David J. (2022) Trends in Chemistry, 4, 378-391. doi:10.1016/j.trechm.2022.02.004
  7. Generating ensembles of dynamic misfolding proteins. Karamanos, Theodoros K. , Kalverda, Arnout P. and Radford, Sheena E. (2022) Frontiers in Neuroscience, 16, . doi:10.3389/fnins.2022.881534
  8. Roll out the barrel! Outer membrane tension resolves an unexpected folding intermediate. Horne, Jim E. and Radford, Sheena E. (2022) Cell, 185, 1107-1109. doi:10.1016/j.cell.2022.03.001
  9. Tuning the rate of aggregation of hiapp into amyloid using small-molecule modulators of assembly. Xu, Yong, Maya-Martinez, Roberto, Guthertz, Nicolas, Heath, George R., Manfield, Iain W., Breeze, Alex,er L., Sobott, Frank, Foster, Richard and Radford, Sheena E. (2022) Nature Communications, 13, . doi:10.1038/s41467-022-28660-7
  10. Global proteotoxicity caused by human beta(2) microglobulin variants impairs the unfolded protein response in C. elegans. Good, Sarah C. , Dewison, Katherine M. , Radford, Sheena E. and van Oosten-Hawle, Patricija (2021) international Journal of Molecular Sciences, 22, . doi:10.3390/ijms221910752
  11. Alphafold: a special issue and a special time for protein science. Serpell, Louise C. , Radford, Sheena E. and Otzen, Daniel E. (2021) Journal of Molecular Biology, 433, . doi:
  12. The role of membrane destabilisation and protein dynamics in bam catalysed omp folding. White, Paul , Haysom, Samuel F. , Iadanza, Matthew G. , Higgins, Anna J. , Machin, Jonathan M. , Whitehouse, James M. , Horne, Jim E. , Schiffrin, Bob , Carpenter-Platt, Charlotte , Calabrese, Antonio N. , Storek, Kelly M. , Rutherford, Steven T. , Brockwell, David J. , Ranson, Neil A. and Radford, Sheena E. (2021) Nature Communications, 12, . doi:10.1038/s41467-021-24432-x
  13. Finding the sweet spot for chaperone activity. Radford, Sheena E. and Karamanos, Theodoros K. (2021) Nature Chemistry, 13, 397-399. doi:10.1038/s41557-021-00691-5
  14. Brazilin removes toxic alpha-synuclein and seeding competent assemblies from parkinson brain by altering conformational equilibrium. Nahass, George R. , Sun, Yuanzi , Xu, Yong , Batchelor, Mark , Reilly, Madeleine , Benilova, Iryna , Kedia, Niraja , Spehar, Kevin , Sobott, Frank , Sessions, Richard B. , Caughey, Byron , Radford, Sheena E. , Jat, Parmjit S. , Collinge, John and Bieschke, Jan (2021) Journal of Molecular Biology, 433, . doi:10.1016/j.jmb.2021.166878
  15. De novo design of transmembrane beta barrels. Vorobieva, Anastassia A. , White, Paul , Liang, Binyong , Horne, Jim E. , Bera, Asim K. , Chow, Cameron M. , Gerben, Stacey , Marx, Sinduja , Kang, Alex , Stiving, Alyssa Q. , Harvey, Sophie R. , Marx, Dagan C. , Khan, G. Nasir , Fleming, Karen G. , Wysocki, Vicki H. , Brockwell, David J. , Tamm, Lukas K. , Radford, Sheena E. and Baker, David (2021) Science, 371, 801+. doi:10.1126/science.abc8182
  16. Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for Type II diabetes. Milardi, Danilo , Gazit, Ehud , Radford, Sheena E. , Xu, Yong , Gallardo, Rodrigo U. , Caflisch, Amedeo , Westermark, Gunilla T. , Westermark, Per , La Rosa, Carmelo and Ramamoorthy, Ayyalusamy (2021) Chemical Reviews, 121, 1845-1893. doi:10.1021/acs.chemrev.0c00981
  17. Investigation of D76N beta(2)-microglobulin using protein footprinting and structural mass spectrometry. Cornwell, Owen , Ault, James R. , Bond, Nicholas J. , Radford, Sheena E. and Ashcroft, Alison E. (2021) Journal of the American Society for Mass Spectrometry, 32, 1583-1592. doi:10.1021/jasms.0c00438
  18. Visualizing and trapping transient oligomers in amyloid assembly pathways. Cawood, Emma E. , Karamanos, Theodoros K. , Wilson, Andrew J. and Radford, Sheena E. (2021) Biophysical Chemistry, 268, . doi:10.1016/j.bpc.2020.106505
  19. Modulation of amyloidogenic protein self-assembly using tethered small molecules. Cawood, Emma E. , Guthertz, Nicolas , Ebo, Jessica S. , Karamanos, Theodoros K. , Radford, Sheena E. and Wilson, Andrew J. (2020) Journal of the American Chemical Society, 142, 20845-20854. doi:10.1021/jacs.0c10629
  20. Distortion of the bilayer and dynamics of the BAM complex in lipid nanodiscs. Iadanza, Matthew G. , Schiffrin, Bob , White, Paul , Watson, Matthew A. , Horne, Jim E. , Higgins, Anna J. , Calabrese, Antonio N. , Brockwell, David J. , Tuma, Roman , Kalli, Antreas C. , Radford, Sheena E. and Ranson, Neil A. (2020) Communications Biology, 3, . doi:10.1038/s42003-020-01419-w
  21. Looking beyond the core: the role of flanking regions in the aggregation of amyloidogenic peptides and proteins. Ulamec, Sabine M. , Brockwell, David J. and Radford, Sheena E. (2020) Frontiers in Neuroscience, 14, . doi:10.3389/fnins.2020.611285
  22. Modulation of beta-amyloid fibril formation in Alzheimer's disease by microglia and infection. Brown, Madeleine R. , Radford, Sheena E. and Hewitt, Eric W. (2020) Frontiers in Molecular Neuroscience, 13, . doi:10.3389/fnmol.2020.609073
  23. Structural insights into peptide self-assembly using photo-induced crosslinking experiments and discontinuous molecular dynamics. Bunce, Samuel J. , Wang, Yiming , Radford, Sheena E. , Wilson, Andrew J. and Hall, Carol K. (2020) Aiche Journal, , . doi:10.1002/aic.17101
  24. The uniqueness of flow in probing the aggregation behavior of clinically relevant antibodies. Willis, Leon F. , Kumar, Amit , Jain, Tushar , Caffrey, Isabelle , Xu, Yingda , Radford, Sheena E. , Kapur, Nikil , Vasquez, Maximiliano and Brockwell, David J. (2020) Engineering Reports, 27, 1094. doi:10.1002/eng2.12147
  25. Fibril structures of diabetes-related amylin variants reveal a basis for surface-templated assembly. Gallardo, Rodrigo , Iadanza, Matthew G. , Xu, Yong , Heath, George R. , Foster, Richard , Radford, Sheena E. and Ranson, Neil A. (2020) Nature Structural & Molecular Biology, 27, 1094. doi:10.1038/s41594-020-00525-x, Early Access Date = OCT 2020
  26. Potential human transmission of amyloid beta pathology: surveillance and risks. Lauwers, Elsa , Lalli, Giovanna , Br,ner, Sebastian , Collinge, John , Compernolle, Veerle , Duyckaerts, Charles , Edgren, Gustaf , Haik, Stephane , Hardy, John , Helmy, Adel , Ivinson, Adrian J. , Jaunmuktane, Zane , Jucker, Mathias , Knight, Richard , Lemmens, Robin , Lin, I-Chun , Love, Seth , Mead, Simon , Perry, V. Hugh , Pickett, James , Poppy, Guy , Radford, Sheena E. , Rousseau, Frederic , Routledge, Carol , Schiavo, Giampietro , Schymkowitz, Joost , Selkoe, Dennis J. , Smith, Colin , Thal, Dietmar R. , Theys, Tom , Tiberghien, Pierre , van den Burg, Peter , V,ekerckhove, Philippe , Walton, Clare , Zaaijer, Hans L. , Zetterberg, Henrik and De Strooper, Bart (2020) Lancet Neurology, 19, 872-878. doi:
  27. The role of the IT-state in D76N beta(2)-microglobulin amyloid assembly: a crucial intermediate or an innocuous bystander?. Smith, I, Hugh , Guthertz, Nicolas , Cawood, Emma E. , Maya-Martinez, Roberto , Breeze, Alex,er L. and Radford, Sheena E. (2020) Journal of Biological Chemistry, 295, 12474-12484. doi:10.1074/jbc.RA120.014901
  28. Spot the difference: function versus toxicity in amyloid fibrils. Ulamec, Sabine M. and Radford, Sheena E. (2020) Trends in Biochemical Sciences, 45, 635-636. doi:10.1016/j.tibs.2020.04.007
  29. Role of the lipid bilayer in outer membrane protein folding in gram-negative bacteria. Horne, Jim E. , Brockwell, David J. and Radford, Sheena E. (2020) Journal of Biological Chemistry, 295, 10340-10367. doi:10.1074/jbc.REV120.011473
  30. Macromolecular crowding enhances the detection of DNA and proteins by a solid-state nanopore. Chau, Chalmers C. , Radford, Sheena E. , Hewitt, Eric W. and Actis, Paolo (2020) Nano Letters, 20, 5553-5561. doi:10.1021/acs.nanolett.0c02246
  31. Pyxlinkviewer: a flexible tool for visualization of protein chemical crosslinking data within thepymolmolecular graphics system. Schiffrin, Bob , Radford, Sheena E. , Brockwell, David J. and Calabrese, Antonio N. (2020) Protein Science, 29, 1851-1857. doi:10.1002/pro.3902, Early Access Date = JUL 2020
  32. Structural insight into the formation of lipoprotein-beta-barrel complexes. Rodriguez-Alonso, Raquel , Letoquart, Juliette , Van Son Nguyen , Louis, Gwennaelle , Calabrese, Antonio N. , Iorga, Bogdan I. , Radford, Sheena E. , Cho, Seung-Hyun , Remaut, Han and Collet, Jean-Francois () Nature Chemical Biology, , . doi:10.1038/s41589-020-0575-0, Early Access Date = JUN 2020
  33. Inter-domain dynamics in the chaperone SurA and multi-site binding to its outer membrane protein clients. Calabrese, Antonio N. , Schiffrin, Bob , Watson, Matthew , Karamanos, Theodoros K. , Walko, Martin , Humes, Julia R. , Horne, Jim E. , White, Paul , Wilson, Andrew J. , Kalli, Antreas C. , Tuma, Roman , Ashcroft, Alison E. , Brockwell, David J. and Radford, Sheena E. (2020) Nature Communications, 11, . doi:10.1038/s41467-020-15702-1
  34. An in vivo platform to select and evolve aggregation-resistant proteins. Ebo, Jessica S. , Saunders, Janet C. , Devine, Paul W. A. , Gordon, Alice M. , Warwick, Amy S. , Schiffrin, Bob , Chin, Stacey E. , Engl,, Elizabeth , Button, James D. , Lloyd, Christopher , Bond, Nicholas J. , Ashcroft, Alison E. , Radford, Sheena E. , Lowe, David C. and Brockwell, David J. (2020) Nature Communications, 11, . doi:10.1038/s41467-020-15667-1
  35. A short motif in the N-terminal region of alpha-synuclein is critical for both aggregation and function. Doherty, Ciaran P. A. , Ulamec, Sabine M. , Maya-Martinez, Roberto , Good, Sarah C. , Makepeace, Jemma , Khan, G. Nasir , van Oosten-Hawle, Patricija , Radford, Sheena E. and Brockwell, David J. (2020) Nature Structural & Molecular Biology, 27, 249+. doi:10.1038/s41594-020-0384-x
  36. Amyloid structures: much more than just a cross-beta fold. Gallardo, Rodrigo , Ranson, Neil A. and Radford, Sheena E. (2020) Current Opinion in Structural Biology, 60, 7-16. doi:10.1016/j.sbi.2019.09.001
  37. Using protein engineering to understand and modulate aggregation. Ebo, Jessica S. , Guthertz, Nicolas , Radford, Sheena E. and Brockwell, David J. (2020) Current Opinion in Structural Biology, 60, 157-166. doi:10.1016/j.sbi.2020.01.005
  38. Collagen I weakly interacts with the beta-sheets of beta(2)-microglobulin and enhances conformational exchange to induce amyloid formation. Hoop, Cody L. , Zhu, Jie , Bhattacharya, Shibani , Tobita, Caitlyn A. , Radford, Sheena E. and Baum, Jean (2020) Journal of the American Chemical Society, 142, 1321-1331. doi:10.1021/jacs.9b10421
  39. Homage to Chris Dobson. Baum, Jean , Chiti, Fabrizio , De Simone, Alfonso , Knowles, Tuomas P. J. , Kumita, Janet R. , Radford, Sheena E. , Robinson, Carol V. , Salvatella, Xavier , Valelli, Karen , Vendruscolo, Michele , Pastore, Annalisa and Tartaglia, Gian Gaetano (2019) Frontiers in Molecular Biosciences, 6, . doi:10.3389/fmolb.2019.00137
  40. Long-range conformational changes in monoclonal antibodies revealed using FPOP-LS-MS/MS. Cornwell, Owen , Bond, Nicholas J. , Radford, Sheena E. and Ashcroft, Alison E. (2019) Analytical Chemistry, 91, 15163-15170. doi:10.1021/acs.analchem.9b03958
  41. Structural mapping of oligomeric intermediates in an amyloid assembly pathway. Karamanos, Theodoros K. , Jackson, Matthew P. , Calabrese, Antonio N. , Goodchild, Sophia C. , Cawood, Emma E. , Section, Gary S. Thompson , Kalverda, Arnout P. , Hewitt, Eric W. and Radford, Sheena E. (2019) Elife, 8, . doi:10.7554/eLife.46574
  42. Extracellular matrix components modulate different stages in (2)-microglobulin amyloid formation. Benseny-Cases, Nuria , Karamanos, Theodoros K. , Hoop, Cody L. , Baum, Jean and Radford, Sheena E. (2019) Journal of Biological Chemistry, 294, 9392-9401. doi:10.1074/jbc.RA119.008300
  43. Molecular insights into the surface-catalyzed secondary nucleation of amyloid-beta(40) (a beta(40)) by the peptide fragment a beta(16-22). Bunce, Samuel J. , Wang, Yiming , Stewart, Katie L. , Ashcroft, Alison E. , Radford, Sheena E. , Hall, Carol K. and Wilson, Andrew J. (2019) Science Advances, 5, . doi:10.1126/sciadv.aav8216
  44. Dual role of ribosome-binding domain of nac as a potent suppressor of protein aggregation and aging-related proteinopathies. Shen, Koning , Gamerdinger, Martin , Chan, Rebecca , Gense, Karina , Martin, Esther M. , Sachs, Nadine , Knight, Patrick D. , Schloemer, Renate , Calabrese, Antonio N. , Stewart, Katie L. , Leiendecker, Lukas , Baghel, Ankit , Radford, Sheena E. , Frydman, Judith and Deuerling, Elke (2019) Molecular Cell, 74, 729+. doi:10.1016/j.molcel.2019.03.012
  45. The role of SurA pplase domains in preventing aggregation of the outer-membrane proteins tOmpA and OmpT. Humes, Julia R. , Schiffrin, Bob , Calabrese, Antonio N. , Higgins, Anna J. , Westhead, David R. , Brockwell, David J. and Radford, Sheena E. (2019) Journal of Molecular Biology, 431, 1267-1283. doi:10.1016/j.jmb.2019.01.032
  46. Thermodynamic phase diagram of amyloid-beta (16-22) peptide. Wang, Yiming , Bunce, Samuel J. , Radford, Sheena E. , Wilson, Andrew J. , Auer, Stefan and Hall, Carol K. (2019) Proceedings of the National Academy of Sciences of the United States of America, 116, 2091-2096. doi:10.1073/pnas.1819592116
  47. Design and synthesis of cysteine-specific labels for photo-crosslinking studies. Walko, Martin , Hewitt, Eric , Radford, Sheena E. and Wilson, Andrew J. (2019) Rsc Advances, 9, 7610-7614. doi:10.1039/c8ra10436k
  48. Rapid mapping of protein interactions using tag-transfer photocrosslinkers. Horne, Jim E. , Walko, Martin , Calabrese, Antonio N. , Levenstein, Mark A. , Brockwell, David J. , Kapur, Nikil , Wilson, Andrew J. and Radford, Sheena E. (2018) Angewandte Chemie-international Edition, 57, 16688-16692. doi:10.1002/anie.201809149
  49. A new era for understanding amyloid structures and disease. Iadanza, Matthew G. , Jackson, Matthew P. , Hewitt, Eric W. , Ranson, Neil A. and Radford, Sheena E. (2018) Nature Reviews Molecular Cell Biology, 19, 755-773. doi:10.1038/s41580-018-0060-8
  50. Comparing hydrogen deuterium exchange and fast photochemical oxidation of proteins: a structural characterisation of wild-type and Delta N6 beta(2)-microglobulin. Cornwell, Owen , Radford, Sheena E. , Ashcroft, Alison E. and Ault, James R. (2018) Journal of the American Society for Mass Spectrometry, 29, 2413-2426. doi:10.1007/s13361-018-2067-y
  51. Orientation of a diagnostic ligand bound to macroscopically aligned amyloid-beta fibrils determined by solid-state NMR. Townsend, David , Hughes, Eleri , Stewart, Katie L. , Griffin, John M. , Radford, Sheena E. and Middleton, David A. (2018) Journal of Physical Chemistry Letters, 9, 6611-6615. doi:10.1021/acs.jpclett.8b02448
  52. The structure of a beta(2)-microglobulin fibril suggests a molecular basis for its amyloid polymorphism. Iadanza, Matthew G. , Silvers, Robert , Boardman, Joshua , Smith, Hugh I. , Karamanos, Theodoros K. , Debelouchina, Galia T. , Su, Yongchao , Griffin, Robert G. , Ranson, Neil A. and Radford, Sheena E. (2018) Nature Communications, 9, . doi:10.1038/s41467-018-06761-6
  53. Mass spectrometry-enabled structural biology of membrane proteins. Calabrese, Antonio N. and Radford, Sheena E. (2018) Methods, 147, 187-205. doi:10.1016/j.ymeth.2018.02.020
  54. Epigallocatechin-3-gallate remodels apolipoprotein a-i amyloid fibrils into soluble oligomers in the presence of heparin. Townsend, David , Hughes, Eleri , Akien, Geoffrey , Stewart, Katie L. , Radford, Sheena E. , Rochester, David and Middleton, David A. (2018) Journal of Biological Chemistry, 293, 12877-12893. doi:10.1074/jbc.RA118.002038
  55. A peptide-display protein scaffold to facilitate single molecule force studies of aggregation-prone peptides. Doherty, Ciaran P. A. , Young, Lydia M. , Karamanos, Theodoros K. , Smith, Hugh I. , Jackson, Matthew P. , Radford, Sheena E. and Brockwell, David J. (2018) Protein Science, 27, 1205-1217. doi:10.1002/pro.3386
  56. The role of beta-barrels 1 and 2 in the enzymatic activity of factor xiii a-subunit. Hethershaw, E. L. , Adamson, P. J. , Smith, K. A. , Goldsberry, W. N. , Pease, R. J. , Radford, S. E. , Grant, P. J. , Ariens, R. A. S. , Maurer, M. C. and Philippou, H. (2018) Journal of Thrombosis and Haemostasis, 16, 1391-1401. doi:10.1111/jth.14128
  57. Dynamic action of the sec machinery during initiation, protein translocation and termination. Fessl, Tomas , Watkins, Daniel , Oatley, Peter , Allen, William John , Corey, Robin Adam , Horne, Jim , Baldwin, Steve A. , Radford, Sheena E. , Collinson, Ian and Tuma, Roman (2018) Elife, 7, . doi:10.7554/eLife.35112
  58. Conformational flexibility within the nascent polypeptide-associated complex enables its interactions with structurally diverse client proteins. Martin, Esther M. , Jackson, Matthew P. , Gamerdinger, Martin , Gense, Karina , Karamonos, Theodoros K. , Humes, Julia R. , Deuerling, Elke , Ashcroft, Alison E. and Radford, Sheena E. (2018) Journal of Biological Chemistry, 293, 8554-8568. doi:10.1074/jbc.RA117.001568
  59. Using extensional flow to reveal diverse aggregation landscapes for three IgG1 molecules. Willis, Leon F. , Kumar, Amit , Dobson, John , Bond, Nicholas J. , Lowe, David , Turner, Richard , Radford, Sheena E. , Kapur, Nikil and Brockwell, David J. (2018) Biotechnology and Bioengineering, 115, 1216-1225. doi:10.1002/bit.26543
  60. Identification of a novel site of interaction between ataxin-3 and the amyloid aggregation inhibitor polyglutamine binding peptide 1. Knight, Patrick D. , Karamanos, Theodoros K. , Radford, Sheena E. and Ashcroft, Alison E. (2018) European Journal of Mass Spectrometry, 24, 129-140. doi:10.1177/1469066717729298
  61. Outer membrane protein folding from an energy landscape perspective. Schiffrin, Bob , Brockwell, David J. and Radford, Sheena E. (2017) Bmc Biology, 15, . doi:10.1186/s12915-017-0464-5
  62. Effects of periplasmic chaperones and membrane thickness on bama-catalyzed outer-membrane protein folding. Schiffrin, Bob , Calabrese, Antonio N. , Higgins, Anna J. , Humes, Julia R. , Ashcroft, Alison E. , Kalli, Antreas C. , Brockwell, David J. and Radford, Sheena E. (2017) Journal of Molecular Biology, 429, 3776-3792. doi:10.1016/j.jmb.2017.09.008
  63. Topological dissection of the membrane transport protein mhp1 derived from cysteine accessibility and mass spectrometry. Calabrese, Antonio N. , Jackson, Scott M. , Jones, Lynsey N. , Beckstein, Oliver , Heinkel, Florian , Gsponer, Joerg , Sharples, David , Sans, Marta , Kokkinidou, Maria , Pearson, Arwen R. , Radford, Sheena E. , Ashcroft, Alison E. and Henderson, Peter J. F. (2017) Analytical Chemistry, 89, 8844-8852. doi:10.1021/acs.analchem.7b01310
  64. Investigating the structural compaction of biomolecules upon transition to the gas-phase using esi-twims-ms. Devine, Paul W. A. , Fisher, Henry C. , Calabrese, Antonio N. , Whelan, Fiona , Higazi, Daniel R. , Potts, Jennifer R. , Lowe, David C. , Radford, Sheena E. and Ashcroft, Alison E. (2017) Journal of the American Society for Mass Spectrometry, 28, 1855-1862. doi:10.1007/s13361-017-1689-9
  65. Molecular origins of the compatibility between glycosaminoglycans and a beta 40 amyloid fibrils. Stewart, Katie L. , Hughes, Eleri , Yates, Edwin A. , Middleton, David A. and Radford, Sheena E. (2017) Journal of Molecular Biology, 429, 2449-2462. doi:10.1016/j.jmb.2017.07.003
  66. Small molecule probes of protein aggregation. Young, Lydia M. , Ashcroft, Alison E. and Radford, Sheena E. (2017) Current Opinion in Chemical Biology, 39, 90-99. doi:10.1016/j.cbpa.2017.06.008
  67. Lateral opening in the intact beta-barrel assembly machinery captured by cryo-EM. Higgins, A. J. , Iadanza, M. G. , Schiffrin, B. , Calabrese, A. N. , Humes, J. R. , Brockwell, D. J. , Ashcroft, A. E. , Ranson, N. A. and Radford, S. E. (2017) European Biophysics Journal With Biophysics Letters, 46, S346. doi:
  68. Complementary cross-linking and fluorescence studies of outer membrane protein biogenesis in vitro. Horne, J. E. , Radford, S. E. and Brockwell, D. J. (2017) European Biophysics Journal With Biophysics Letters, 46, S346. doi:
  69. Identifying the contributions of the different domains within SurA on outer member protein folding. Humes, J. R. , Higgins, A. J. , Brockwell, D. J. and Radford, S. E. (2017) European Biophysics Journal With Biophysics Letters, 46, S346. doi:
  70. The challenges and opportunities of understanding protein folding and misfolding in health and disease. Radford, S. E. (2017) European Biophysics Journal With Biophysics Letters, 46, S44. doi:
  71. Understanding co-polymerization in amyloid formation by direct observation of mixed oligomers. Young, Lydia M. , Tu, Ling-Hsien , Raleigh, Daniel P. , Ashcroft, Alison E. and Radford, Sheena E. (2017) Chemical Science, 8, 5030-5040. doi:10.1039/c7sc00620a
  72. Inducing protein aggregation by extensional flow. Dobson, John , Kumar, Amit , Willis, Leon F. , Tuma, Roman , Higazi, Daniel R. , Turner, Richard , Lowe, David C. , Ashcroft, Alison E. , Radford, Sheena E. , Kapur, Nikil and Brockwell, David J. (2017) Proceedings of the National Academy of Sciences of the United States of America, 114, 4673-4678. doi:10.1073/pnas.1702724114
  73. Fretting about outer membrane protein biogenesis. How exactly do they fold?. Horne, Jim E. , Brockwell, David J. and Radford, Sheena E. (2017) Biophysical Journal, 112, 205A. doi:10.1016/j.bpj.2016.11.1131
  74. FPOP-LC-MS-MS suggests differences in interaction sites of amphipols and detergents with outer membrane proteins. Watkinson, Thomas G. , Calabrese, Antonio N. , Ault, James R. , Radford, Sheena E. and Ashcroft, Alison E. (2017) Journal of the American Society for Mass Spectrometry, 28, 50-55. doi:10.1007/s13361-016-1421-1
  75. Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo. Dobson, Claire L. , Devine, Paul W. A. , Phillips, Jonathan J. , Higazi, Daniel R. , Lloyd, Christopher , Popovic, Bojana , Arnold, Joanne , Buchanan, Andrew , Lewis, Arthur , Goodman, Joanne , van der Walle, Christopher F. , Thornton, Peter , Vinall, Lisa , Lowne, David , Aagaard, Anna , Olsson, Lise-Lotte , Wollberg, Anna Ridderstad , Welsh, Fraser , Karamanos, Theodoros K. , Pashley, Clare L. , Iadanza, Matthew G. , Ranson, Neil A. , Ashcroft, Alison E. , Kippen, Alistair D. , Vaughan, Tristan J. , Radford, Sheena E. and Lowe, David C. (2016) Scientific Reports, 6, . doi:10.1038/srep38644
  76. Lateral opening in the intact beta-barrel assembly machinery captured by cryo-EM. Iadanza, Matthew G. , Higgins, Anna J. , Schiffrin, Bob , Calabrese, Antonio N. , Brockwell, David J. , Ashcroft, Alison E. , Radford, Sheena E. and Ranson, Neil A. (2016) Nature Communications, 7, . doi:10.1038/ncomms12865
  77. Skp is a multivalent chaperone of outer-membrane proteins. Schiffrin, Bob , Calabrese, Antonio N. , Devine, Paul W. A. , Harris, Sarah A. , Ashcroft, Alison E. , Brockwell, David J. and Radford, Sheena E. (2016) Nature Structural & Molecular Biology, 23, 786-793. doi:10.1038/nsmb.3266
  78. Atomic details of the interactions of glycosaminoglycans with amyloid-beta fibrils. Stewart, Katie L. , Hughes, Eleri , Yates, Edwin A. , Akien, Geoffrey R. , Huang, Teng-Yi , Lima, Marcelo A. , Rudd, Timothy R. , Guerrini, Marco , Hung, Shang-Cheng , Radford, Sheena E. and Middleton, David A. (2016) Journal of the American Chemical Society, 138, 8328-8331. doi:10.1021/jacs.6b02816
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“ I think that we shall be able to get a more thorough understanding of the nature of disease in general by investigating the molecules that make up the human body, including the abnormal molecules, and that this understanding will permit...the problem of disease to be attacked in a more straightforward manner such that new methods of therapy will be developed. ”